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Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial.
Lancet Neurol. 2023.
PMID: 36403580
Clinical Trial.
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Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial.
Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators.
Lanfranconi S, et al.
Lancet Neurol. 2023 Jan;22(1):35-44. doi: 10.1016/S1474-4422(22)00409-4. Epub 2022 Nov 17.
Lancet Neurol. 2023.
PMID: 36403580
Free article.
Clinical Trial.
METHODS: We conducted a randomised, open-label, blinded-endpoint, phase 2 pilot trial (Treat_CCM) at six national reference centres for rare diseases in Italy. ...A definitive phase 3 trial …
METHODS: We conducted a randomised, open-label, blinded-endpoint, phase 2 pilot t …
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Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial.
Lanfranconi S, Scola E, Bertani GA, Zarino B, Pallini R, d'Alessandris G, Mazzon E, Marino S, Carriero MR, Scelzo E, Faragò G, Castori M, Fusco C, Petracca A, d'Agruma L, Tassi L, d'Orio P, Lampugnani MG, Nicolis EB, Vasamì A, Novelli D, Torri V, Meessen JMTA, Al-Shahi Salman R, Dejana E, Latini R; Treat-CCM Investigators.
Lanfranconi S, et al.
Trials. 2020 May 12;21(1):401. doi: 10.1186/s13063-020-4202-x.
Trials. 2020.
PMID: 32398113
Free PMC article.
Clinical Trial.
BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular malformations characterized by clusters of enlarged leaky capillaries in the central nervous system. ...Case reports suggest that propranolol might modify dise …
BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular malformations characterized by clusters of enla …
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