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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.
Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, Bose S, McCarthy D, Zhu RR, Santora L, Davis-Taber R, Kunes Y, Fung E, Schwartz A, Sakorafas P, Gu J, Tarcsa E, Murtaza A, Ghayur T. Wu C, et al. Among authors: sakorafas p. Nat Biotechnol. 2007 Nov;25(11):1290-7. doi: 10.1038/nbt1345. Epub 2007 Oct 14. Nat Biotechnol. 2007. PMID: 17934452
Small-molecule control of antibody N-glycosylation in engineered mammalian cells.
Chang MM, Gaidukov L, Jung G, Tseng WA, Scarcelli JJ, Cornell R, Marshall JK, Lyles JL, Sakorafas P, Chu AA, Cote K, Tzvetkova B, Dolatshahi S, Sumit M, Mulukutla BC, Lauffenburger DA, Figueroa B Jr, Summers NM, Lu TK, Weiss R. Chang MM, et al. Among authors: sakorafas p. Nat Chem Biol. 2019 Jul;15(7):730-736. doi: 10.1038/s41589-019-0288-4. Epub 2019 May 20. Nat Chem Biol. 2019. PMID: 31110306
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Avery LB, Wade J, Wang M, Tam A, King A, Piche-Nicholas N, Kavosi MS, Penn S, Cirelli D, Kurz JC, Zhang M, Cunningham O, Jones R, Fennell BJ, McDonnell B, Sakorafas P, Apgar J, Finlay WJ, Lin L, Bloom L, O'Hara DM. Avery LB, et al. Among authors: sakorafas p. MAbs. 2018 Feb/Mar;10(2):244-255. doi: 10.1080/19420862.2017.1417718. Epub 2018 Jan 29. MAbs. 2018. PMID: 29271699 Free PMC article.
15 results