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Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity.
Sacco G, Giampietro R, Salvatorelli E, Menna P, Bertani N, Graiani G, Animati F, Goso C, Maggi CA, Manzini S, Minotti G. Sacco G, et al. Among authors: salvatorelli e. Br J Pharmacol. 2003 Jun;139(3):641-51. doi: 10.1038/sj.bjp.0705270. Br J Pharmacol. 2003. PMID: 12788824 Free PMC article.
Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.
Salvatorelli E, Guarnieri S, Menna P, Liberi G, Calafiore AM, Mariggiò MA, Mordente A, Gianni L, Minotti G. Salvatorelli E, et al. J Biol Chem. 2006 Apr 21;281(16):10990-1001. doi: 10.1074/jbc.M508343200. Epub 2006 Jan 19. J Biol Chem. 2006. PMID: 16423826 Free article.
57 results