Radical-mediated enzymatic methylation: a tale of two SAMS.
Zhang Q, van der Donk WA, Liu W.
Zhang Q, et al.
Acc Chem Res. 2012 Apr 17;45(4):555-64. doi: 10.1021/ar200202c. Epub 2011 Nov 18.
Acc Chem Res. 2012.
PMID: 22097883
Free PMC article.
Review.
The enzymes known to catalyze these reactions all belong to the radical SAM superfamily. This family of enzymes utilizes a specialized [4Fe-4S] cluster for reductive cleavage of SAM to yield a highly reactive 5'-deoxyadenosyl (dAdo) radical. ...The diverse strategie …
The enzymes known to catalyze these reactions all belong to the radical SAM superfamily. This family of enzymes utilizes a specialize …