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SAMHD1 in cancer: curse or cure?
Schott K, Majer C, Bulashevska A, Childs L, Schmidt MHH, Rajalingam K, Munder M, König R. Schott K, et al. J Mol Med (Berl). 2022 Mar;100(3):351-372. doi: 10.1007/s00109-021-02131-w. Epub 2021 Sep 4. J Mol Med (Berl). 2022. PMID: 34480199 Free PMC article. Review.
As outlined in this review, SAMHD1 has been reported to be mutated in a variety of cancer types and the expression of SAMHD1 is dysregulated in many cancers. ...The present review summarizes the negative role of SAMHD1 in chemotherapy sensitivity, highlights …
As outlined in this review, SAMHD1 has been reported to be mutated in a variety of cancer types and the expression of SAMHD1 i …
SAMHD1 and Viral Ways around It.
Deutschmann J, Gramberg T. Deutschmann J, et al. Viruses. 2021 Mar 2;13(3):395. doi: 10.3390/v13030395. Viruses. 2021. PMID: 33801276 Free PMC article. Review.
While some viruses are efficiently restricted by SAMHD1, others have developed evasion mechanisms that antagonize the antiviral activity of SAMHD1. Within this review, we summarize the different cellular functions of SAMHD1 and highlight the countermeasures v …
While some viruses are efficiently restricted by SAMHD1, others have developed evasion mechanisms that antagonize the antiviral activ …
SAMHD1 Suppression of Antiviral Immune Responses.
Chen S, Bonifati S, Qin Z, St Gelais C, Wu L. Chen S, et al. Trends Microbiol. 2019 Mar;27(3):254-267. doi: 10.1016/j.tim.2018.09.009. Epub 2018 Oct 15. Trends Microbiol. 2019. PMID: 30336972 Free PMC article. Review.
SAMHD1 can also modulate antibody production in adaptive immune responses. In this review, we summarize how SAMHD1 regulates antiviral immune responses through distinct mechanisms, and discuss the implications of these new functions of SAMHD1. ...
SAMHD1 can also modulate antibody production in adaptive immune responses. In this review, we summarize how SAMHD1 regulates a …
SAMHD1 Functions and Human Diseases.
Coggins SA, Mahboubi B, Schinazi RF, Kim B. Coggins SA, et al. Viruses. 2020 Mar 31;12(4):382. doi: 10.3390/v12040382. Viruses. 2020. PMID: 32244340 Free PMC article. Review.
Finally, a series of SAMHD1 mutations were also reported in various cancer cell types while why SAMHD1 is mutated in these cancer cells remains to investigated. Here, we reviewed a series of studies that have begun illuminating the highly diverse roles of SAMHD1 …
Finally, a series of SAMHD1 mutations were also reported in various cancer cell types while why SAMHD1 is mutated in these can …
Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies.
Wang T, Liu P, Yang J. Wang T, et al. Genes Dis. 2022 Jun 26;10(3):891-900. doi: 10.1016/j.gendis.2022.06.001. eCollection 2023 May. Genes Dis. 2022. PMID: 37396510 Free PMC article. Review.
SAMHD1 expression in acute myeloid leukemia predicts inferior prognosis. Recently, it has been revealed that SAMHD1 mediates the resistance to anti-cancer drugs. This review will focus on SAMHD1 function and regulation, the association between SAMHD1 a …
SAMHD1 expression in acute myeloid leukemia predicts inferior prognosis. Recently, it has been revealed that SAMHD1 mediates t …
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. Schumann T, et al. J Exp Med. 2023 Jan 2;220(1):e20220829. doi: 10.1084/jem.20220829. Epub 2022 Nov 8. J Exp Med. 2023. PMID: 36346347 Free PMC article.
Here, we show that low-level chronic DNA damage in mice lacking the Aicardi-Goutieres syndrome gene SAMHD1 reduced tumor-free survival when crossed to a p53-deficient, but not to a DNA mismatch repair-deficient background. ...Our work positions cGAS/STING upstream of tonic …
Here, we show that low-level chronic DNA damage in mice lacking the Aicardi-Goutieres syndrome gene SAMHD1 reduced tumor-free surviva …
Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies.
Majer C, Schüssler JM, König R. Majer C, et al. Med Microbiol Immunol. 2019 Aug;208(3-4):513-529. doi: 10.1007/s00430-019-00593-x. Epub 2019 Mar 16. Med Microbiol Immunol. 2019. PMID: 30879196 Review.
SAMHD1 was initially described for its ability to efficiently restrict HIV-1 replication in myeloid cells and resting CD4(+) T cells. ...Furthermore, we aim to highlight different ways how viruses counteract SAMHD1-mediated restriction to bypass the SAMHD1-me …
SAMHD1 was initially described for its ability to efficiently restrict HIV-1 replication in myeloid cells and resting CD4(+) T cells. …
SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma.
Li Y, Gao Y, Jiang X, Cheng Y, Zhang J, Xu L, Liu X, Huang Z, Xie C, Gong Y. Li Y, et al. J Transl Med. 2022 Dec 29;20(1):628. doi: 10.1186/s12967-022-03844-3. J Transl Med. 2022. PMID: 36578072 Free PMC article.
The translocation of IFI16 from nucleus to cytosol was detected in SAMHD1-deficient cells. IFI16 and STING were acquired in the activation of STING-IFN-I pathway in SAMHD1-deficient cells. SAMHD1 silencing in LUAD cells promoted macrophage M1 polarization in …
The translocation of IFI16 from nucleus to cytosol was detected in SAMHD1-deficient cells. IFI16 and STING were acquired in the activ …
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X. Cai Y, et al. Int J Biol Sci. 2023 Aug 28;19(14):4627-4643. doi: 10.7150/ijbs.85236. eCollection 2023. Int J Biol Sci. 2023. PMID: 37781035 Free PMC article.
High level of SAMHD1 was associated with poor prognosis in DLBCL patients. Down-regulation of SAMHD1 inhibited DLBCL cell proliferation both in vitro and in vivo. Moreover, we found that SAMHD1 deficiency induced DNA damage and promoted the expression of DNA …
High level of SAMHD1 was associated with poor prognosis in DLBCL patients. Down-regulation of SAMHD1 inhibited DLBCL cell prol …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Mauney CH, Hollis T. Mauney CH, et al. Autoimmunity. 2018 May;51(3):96-110. doi: 10.1080/08916934.2018.1454912. Epub 2018 Mar 27. Autoimmunity. 2018. PMID: 29583030 Free PMC article. Review.
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. ...Additionally, SAMHD1 functions as a restriction fact …
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrola …
770 results