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Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.
Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y. Nakamura K, et al. Among authors: sasajima j. PLoS One. 2010 Jan 21;5(1):e8824. doi: 10.1371/journal.pone.0008824. PLoS One. 2010. PMID: 20098680 Free PMC article.
Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.
Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, Nishikawa T, Nakano Y, Yanagawa N, Sato K, Maemoto A, Tanno S, Okumura T, Karasaki H, Kono T, Fujiya M, Ashida T, Chung DC, Kohgo Y. Yamazaki M, et al. Among authors: sasajima j. Cancer Sci. 2008 Jun;99(6):1131-8. doi: 10.1111/j.1349-7006.2008.00795.x. Epub 2008 Apr 14. Cancer Sci. 2008. PMID: 18422746 Free article.
Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.
Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe J, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y. Sasajima J, et al. Cancer Res. 2010 Aug 1;70(15):6283-92. doi: 10.1158/0008-5472.CAN-10-0412. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631070 Free PMC article.
48 results