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Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Berghoff SA, et al. Among authors: sasmita ao. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. Nat Neurosci. 2021. PMID: 33349711 Free PMC article.
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.
Berghoff SA, Spieth L, Sun T, Hosang L, Depp C, Sasmita AO, Vasileva MH, Scholz P, Zhao Y, Krueger-Burg D, Wichert S, Brown ER, Michail K, Nave KA, Bonn S, Odoardi F, Rossner M, Ischebeck T, Edgar JM, Saher G. Berghoff SA, et al. Among authors: sasmita ao. Cell Rep. 2021 Oct 26;37(4):109889. doi: 10.1016/j.celrep.2021.109889. Cell Rep. 2021. PMID: 34706227 Free article.
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.
Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave KA. Depp C, et al. Among authors: sasmita ao. Nature. 2023 Jun;618(7964):349-357. doi: 10.1038/s41586-023-06120-6. Epub 2023 May 31. Nature. 2023. PMID: 37258678 Free PMC article.