Saxena A - Search Results

1

Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.

Savini L, Campiani G, Gaeta A, Pellerano C, Fattorusso C, Chiasserini L, Fedorko JM, Saxena A. Savini L, et al. Among authors: saxena a. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82. doi: 10.1016/s0960-894x(01)00294-3. Bioorg Med Chem Lett. 2001. PMID: 11425559

2

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.

Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, Saxena A. Campiani G, et al. Among authors: saxena a. J Med Chem. 2005 Mar 24;48(6):1919-29. doi: 10.1021/jm049510k. J Med Chem. 2005. PMID: 15771436

3

Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.

Gemma S, Gabellieri E, Huleatt P, Fattorusso C, Borriello M, Catalanotti B, Butini S, De Angelis M, Novellino E, Nacci V, Belinskaya T, Saxena A, Campiani G. Gemma S, et al. Among authors: saxena a. J Med Chem. 2006 Jun 1;49(11):3421-5. doi: 10.1021/jm060257t. J Med Chem. 2006. PMID: 16722663

4

Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.

Butini S, Guarino E, Campiani G, Brindisi M, Coccone SS, Fiorini I, Novellino E, Belinskaya T, Saxena A, Gemma S. Butini S, et al. Among authors: saxena a. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5213-6. doi: 10.1016/j.bmcl.2008.08.076. Epub 2008 Aug 26. Bioorg Med Chem Lett. 2008. PMID: 18786825

5

Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.

Savini L, Gaeta A, Fattorusso C, Catalanotti B, Campiani G, Chiasserini L, Pellerano C, Novellino E, McKissic D, Saxena A. Savini L, et al. Among authors: saxena a. J Med Chem. 2003 Jan 2;46(1):1-4. doi: 10.1021/jm0255668. J Med Chem. 2003. PMID: 12502352

6

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, Fattorusso C. Butini S, et al. Among authors: saxena a. J Med Chem. 2008 Jun 12;51(11):3154-70. doi: 10.1021/jm701253t. Epub 2008 May 15. J Med Chem. 2008. PMID: 18479118

7

Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.

Campiani G, Kozikowski AP, Wang S, Ming L, Nacci V, Saxena A, Doctor BP. Campiani G, et al. Among authors: saxena a. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1413-8. doi: 10.1016/s0960-894x(98)00229-7. Bioorg Med Chem Lett. 1998. PMID: 9871776 Free article.

8

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.

Butini S, Brindisi M, Brogi S, Maramai S, Guarino E, Panico A, Saxena A, Chauhan V, Colombo R, Verga L, De Lorenzi E, Bartolini M, Andrisano V, Novellino E, Campiani G, Gemma S. Butini S, et al. Among authors: saxena a. ACS Med Chem Lett. 2013 Oct 6;4(12):1178-82. doi: 10.1021/ml4002908. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900626 Free PMC article.

9

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.

Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radić Z, Taylor P, Lockridge O, Doctor BP. Saxena A, et al. Eur J Biochem. 2003 Nov;270(22):4447-58. doi: 10.1046/j.1432-1033.2003.03837.x. Eur J Biochem. 2003. PMID: 14622273 Free article.

10

In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger.

Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. Cerasoli DM, et al. Among authors: saxena a. Chem Biol Interact. 2005 Dec 15;157-158:363-5. doi: 10.1016/j.cbi.2005.10.052. Chem Biol Interact. 2005. PMID: 16429486

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