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Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.
Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR. Velardi E, et al. Among authors: scadden dt. J Exp Med. 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20. J Exp Med. 2014. PMID: 25332287 Free PMC article.
Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.
Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N. Fernandez L, et al. Among authors: scadden dt. Exp Hematol. 2008 May;36(5):545-558. doi: 10.1016/j.exphem.2007.12.012. Exp Hematol. 2008. PMID: 18439488 Free PMC article.
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT. Saez B, et al. Among authors: scadden dt. Blood. 2014 Nov 6;124(19):2937-47. doi: 10.1182/blood-2014-08-593426. Epub 2014 Sep 8. Blood. 2014. PMID: 25202142 Free PMC article.
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT. Yu VW, et al. Among authors: scadden dt. J Exp Med. 2015 May 4;212(5):759-74. doi: 10.1084/jem.20141843. Epub 2015 Apr 27. J Exp Med. 2015. PMID: 25918341 Free PMC article.
Hematopoietic Stem Cell and Its Bone Marrow Niche.
Yu VW, Scadden DT. Yu VW, et al. Among authors: scadden dt. Curr Top Dev Biol. 2016;118:21-44. doi: 10.1016/bs.ctdb.2016.01.009. Epub 2016 Mar 21. Curr Top Dev Biol. 2016. PMID: 27137653 Free PMC article. Review.
397 results