Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1954 1
1972 1
1975 1
1976 1
1980 3
1981 1
1986 1
1987 1
1988 1
1990 1
1991 1
1992 1
1993 3
1994 2
1995 1
1996 7
1997 5
1998 8
1999 10
2000 11
2001 13
2002 20
2003 29
2004 14
2005 21
2006 23
2007 33
2008 26
2009 34
2010 33
2011 37
2012 36
2013 75
2014 63
2015 65
2016 61
2017 69
2018 76
2019 81
2020 98
2021 101
2022 114
2023 119
2024 55

Text availability

Article attribute

Article type

Publication date

Search Results

1,200 results

Results by year

Filters applied: . Clear all
Page 1
Retrospective on Cholesterol Homeostasis: The Central Role of Scap.
Brown MS, Radhakrishnan A, Goldstein JL. Brown MS, et al. Annu Rev Biochem. 2018 Jun 20;87:783-807. doi: 10.1146/annurev-biochem-062917-011852. Epub 2017 Aug 25. Annu Rev Biochem. 2018. PMID: 28841344 Free PMC article. Review.
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. ...When cholesterol in ER membranes exceeds a threshold, the sterol binds to Scap, triggering several conformational change …
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammali …
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Kawamura S, et al. J Clin Invest. 2022 Jun 1;132(11):e151895. doi: 10.1172/JCI151895. J Clin Invest. 2022. PMID: 35380992 Free PMC article.
Unexpectedly, SREBP inhibition via deletion of the SREBP cleavage-activating protein (SCAP) in the liver exacerbated liver injury, fibrosis, and carcinogenesis despite markedly reduced hepatic steatosis. ...Supplementation with phosphatidylcholines significantly improved l …
Unexpectedly, SREBP inhibition via deletion of the SREBP cleavage-activating protein (SCAP) in the liver exacerbated liver injury, fi …
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Guo C, Chi Z, Jiang D, Xu T, Yu W, Wang Z, Chen S, Zhang L, Liu Q, Guo X, Zhang X, Li W, Lu L, Wu Y, Song BL, Wang D. Guo C, et al. Immunity. 2018 Nov 20;49(5):842-856.e7. doi: 10.1016/j.immuni.2018.08.021. Epub 2018 Oct 23. Immunity. 2018. PMID: 30366764 Free article.
However, this regulation did not predominantly depend on changes in cholesterol homeostasis controlled by the transcriptional activity of SREBP2, but relied on the escort activity of SCAP. Mechanistically, NLRP3 associated with SCAP-SREBP2 to form a ternary complex …
However, this regulation did not predominantly depend on changes in cholesterol homeostasis controlled by the transcriptional activity of SR …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X. Zheng ZG, et al. Autophagy. 2021 Jul;17(7):1592-1613. doi: 10.1080/15548627.2020.1757955. Epub 2020 May 20. Autophagy. 2021. PMID: 32432943 Free PMC article.
Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism completely distinct from current SCAP inhibitors. Furthermore, we determined that SQSTM1 captured SCAP after its exit from the ER. The …
Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism complete …
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.
Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, Lefai E, Kaur B, Nohturfft A, Ma J, Chakravarti A, Guo D. Cheng C, et al. Cancer Cell. 2015 Nov 9;28(5):569-581. doi: 10.1016/j.ccell.2015.09.021. Cancer Cell. 2015. PMID: 26555173 Free PMC article.
Glycosylation stabilizes SCAP and reduces its association with Insig-1, allowing movement of SCAP/SREBP to the Golgi and consequent proteolytic activation of SREBP. Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven gliobl …
Glycosylation stabilizes SCAP and reduces its association with Insig-1, allowing movement of SCAP/SREBP to the Golgi and conse …
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-kappaB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y. Huang X, et al. Cell Mol Gastroenterol Hepatol. 2022;14(1):1-26. doi: 10.1016/j.jcmgh.2022.03.006. Epub 2022 Mar 31. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35367665 Free PMC article.
METHODS: C57BL/6J wild-type and macrophage SCAP-specific knockout mice (SCAP(deltaM)) were subjected to Paigen diet (PD) feeding induced lean NAFLD. ...Inhibition of macrophage SCAP may represent a new therapeutic strategy for the treatment of lean NAFLD....
METHODS: C57BL/6J wild-type and macrophage SCAP-specific knockout mice (SCAP(deltaM)) were subjected to Paigen diet (PD) feedi …
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.
Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D. Cheng C, et al. Nat Metab. 2022 May;4(5):575-588. doi: 10.1038/s42255-022-00568-y. Epub 2022 May 9. Nat Metab. 2022. PMID: 35534729 Free PMC article.
Notably, 25-hydroxycholesterol blocks ammonia to access its binding site on SCAP. Mutating aspartate D428 to alanine prevents ammonia binding to SCAP, abolishes SREBP-1 activation and suppresses tumour growth. Our study characterizes the unknown role, opposite to st …
Notably, 25-hydroxycholesterol blocks ammonia to access its binding site on SCAP. Mutating aspartate D428 to alanine prevents ammonia …
The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-kappaB.
Fei X, Huang J, Li F, Wang Y, Shao Z, Dong L, Wu Y, Li B, Zhang X, Lv B, Zhao Y, Weng Q, Chen K, Zhang M, Yang S, Zhang C, Zhang M, Li W, Ying S, Sun Q, Chen Z, Shen H. Fei X, et al. Cell Rep. 2023 Jun 27;42(6):112586. doi: 10.1016/j.celrep.2023.112586. Epub 2023 Jun 1. Cell Rep. 2023. PMID: 37267109 Free article.
SREBP cleavage-activating protein (Scap) and sterol regulatory element-binding protein 1 (SREBP1) form a super complex with inhibitors of NF-kappaB alpha (IkappaBalpha) to associate NF-kappaB close to the endoplasmic reticulum (ER). ...Loss of Scap or inhibition of …
SREBP cleavage-activating protein (Scap) and sterol regulatory element-binding protein 1 (SREBP1) form a super complex with inhibitor …
The cellular function of SCAP in metabolic signaling.
Lee SH, Lee JH, Im SS. Lee SH, et al. Exp Mol Med. 2020 May;52(5):724-729. doi: 10.1038/s12276-020-0430-0. Epub 2020 May 8. Exp Mol Med. 2020. PMID: 32385422 Free PMC article. Review.
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic reticulum to the Golgi apparatus, allowing it to regulate cellular triglyceride and …
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP …
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.
Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. Kim JY, et al. Cell Metab. 2022 Oct 4;34(10):1548-1560.e6. doi: 10.1016/j.cmet.2022.08.005. Epub 2022 Aug 29. Cell Metab. 2022. PMID: 36041455 Free PMC article.
Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER stress activates SREBP1/2 via caspase-2. ...Thus, the PIDDosome and SCAP pathways antagonistically modulate nutrient-induced hepatic ER stress to control non-linear tr …
Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER stress activates SREBP1/2 via casp …
1,200 results