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Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution.
Wang J, Chen W, Yue W, Hou W, Rao F, Zhong H, Qi Y, Hong N, Ni T, Jin W. Wang J, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2113504119. doi: 10.1073/pnas.2113504119. Epub 2022 Dec 1. Proc Natl Acad Sci U S A. 2022. PMID: 36454750 Free PMC article.
We further identified 812 genes showing polyA site usage changes between neighboring cell cycles, which were grouped into six clusters, with cell phase-specific functional categories enriched in each cluster. Deletion of one polyA site in MSL1 and SCCPDH results in slower …
We further identified 812 genes showing polyA site usage changes between neighboring cell cycles, which were grouped into six clusters, with …
Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437.
Gagestein B, Stevens AF, Fazio D, Florea BI, van der Wel T, Bakker AT, Fezza F, Dulk HD, Overkleeft HS, Maccarrone M, van der Stelt M. Gagestein B, et al. ACS Chem Biol. 2022 May 20;17(5):1174-1183. doi: 10.1021/acschembio.2c00122. Epub 2022 Apr 28. ACS Chem Biol. 2022. PMID: 35482948 Free PMC article.
Using pac-WOBE, we identified saccharopine dehydrogenase-like oxidoreductase (SCCPDH), vesicle amine transport 1 (VAT1), and ferrochelatase (FECH) as WOBE437-interacting proteins in Neuro-2a cells. Further genetic studies indicated that SCCPDH and VAT1 were not resp …
Using pac-WOBE, we identified saccharopine dehydrogenase-like oxidoreductase (SCCPDH), vesicle amine transport 1 (VAT1), and ferroche …
Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor.
Zheng B, Guo H, Ma N, Ni Y, Xu J, Li L, Hao P, Ding K, Li Z. Zheng B, et al. Chem Asian J. 2018 Sep 17;13(18):2601-2605. doi: 10.1002/asia.201800605. Epub 2018 Aug 7. Chem Asian J. 2018. PMID: 29939481
To further identify the cellular on/off targets, in this study, competitive affinity-based proteome profiling was carried out, leading to the discovery of several unknown cellular targets such as BCAP31, LPCAT3, POR, TM9SF3, SCCPDH and CANX. In addition, trans-cyclooctene …
To further identify the cellular on/off targets, in this study, competitive affinity-based proteome profiling was carried out, leading to th …
Transcriptome analysis reveals ADAMTS15 is a potential inflammation-related gene in remote ischemic postconditioning.
Zuo B, Zhu S, Wang G, Li Z. Zuo B, et al. Front Cardiovasc Med. 2023 May 10;10:1089151. doi: 10.3389/fcvm.2023.1089151. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37234367 Free PMC article.
This transcriptome analysis showed that 2 genes were up-regulated (Prodh1 and ADAMTS15) and 5 genes (Caspase-6, Claudin-5, Sccpdh, Robo4 and AABR07011951.1) were down-regulated in the RIPostC group. ...
This transcriptome analysis showed that 2 genes were up-regulated (Prodh1 and ADAMTS15) and 5 genes (Caspase-6, Claudin-5, Sccpdh, Ro …
Proteomic Response of Rat Pituitary Under Chronic Mild Stress Reveals Insights Into Vulnerability and Resistance to Anxiety or Depression.
Tian F, Liu D, Chen J, Liao W, Gong W, Huang R, Xie L, Yi F, Zhou J. Tian F, et al. Front Genet. 2021 Sep 17;12:751999. doi: 10.3389/fgene.2021.751999. eCollection 2021. Front Genet. 2021. PMID: 34603401 Free PMC article.
Afterwards, parallel reaction monitoring-based independent analysis found out that expression alterations in Oxct1, Sec24c, Ppp1cb, Dock1, and Coq3; Lama1, Glb1, Gapdh, Sccpdh, and Renbp; Sephs1, Nup188, Spp1, Prodh1, and Srm were specifically linked to depression-suscepti …
Afterwards, parallel reaction monitoring-based independent analysis found out that expression alterations in Oxct1, Sec24c, Ppp1cb, Dock1, a …
Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease.
Dakik H, Mantash S, Nehme A, Kobeissy F, Zabet-Moghaddam M, Mirzaei P, Mechref Y, Gaillard A, Prestoz L, Zibara K. Dakik H, et al. Front Neurosci. 2021 Mar 11;15:621121. doi: 10.3389/fnins.2021.621121. eCollection 2021. Front Neurosci. 2021. PMID: 33776636 Free PMC article.
Notably, seven proteins (Acta1, Atp6v1e1, Eci3, Lypla2, Pip4k2a, Sccpdh, and Sh3gl2) were commonly down-regulated after engraftment in all studied brain regions. ...
Notably, seven proteins (Acta1, Atp6v1e1, Eci3, Lypla2, Pip4k2a, Sccpdh, and Sh3gl2) were commonly down-regulated after engraftment i …