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Year Number of Results
1986 1
1987 1
1989 2
1990 1
1991 4
1992 2
1993 2
1994 5
1995 5
1996 14
1997 10
1998 7
1999 7
2000 14
2001 13
2002 15
2003 27
2004 29
2005 36
2006 37
2007 58
2008 72
2009 74
2010 91
2011 99
2012 116
2013 156
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2016 135
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2020 210
2021 191
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2024 78

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2,301 results

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Page 1
SCD1, autophagy and cancer: implications for therapy.
Ascenzi F, De Vitis C, Maugeri-Saccà M, Napoli C, Ciliberto G, Mancini R. Ascenzi F, et al. J Exp Clin Cancer Res. 2021 Aug 24;40(1):265. doi: 10.1186/s13046-021-02067-6. J Exp Clin Cancer Res. 2021. PMID: 34429143 Free PMC article. Review.
METHODS: This is a narrative review discussing the connection between SCD1 and the autophagic process, along with the modality through which this crosstalk can be exploited for therapeutic purposes. ...SCD1 plays an important role in cancer, promoting cell prolifera …
METHODS: This is a narrative review discussing the connection between SCD1 and the autophagic process, along with the modality throug …
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells.
Xuan Y, Wang H, Yung MM, Chen F, Chan WS, Chan YS, Tsui SK, Ngan HY, Chan KK, Chan DW. Xuan Y, et al. Theranostics. 2022 Apr 24;12(7):3534-3552. doi: 10.7150/thno.70194. eCollection 2022. Theranostics. 2022. PMID: 35547771 Free PMC article.
OvCa patient-derived organoid and mouse model of peritoneal metastases were used to evaluate the combined effect of SCD1/FADS2 inhibitors with cisplatin. Results: We found that two critical fatty acid desaturases, stearoyl-CoA desaturase-1 (SCD1) and acyl-CoA 6-desa …
OvCa patient-derived organoid and mouse model of peritoneal metastases were used to evaluate the combined effect of SCD1/FADS2 inhibi …
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer.
Wong TL, Loh JJ, Lu S, Yan HHN, Siu HC, Xi R, Chan D, Kam MJF, Zhou L, Tong M, Copland JA, Chen L, Yun JP, Leung SY, Ma S. Wong TL, et al. Nat Commun. 2023 May 19;14(1):2861. doi: 10.1038/s41467-023-38581-8. Nat Commun. 2023. PMID: 37208334 Free PMC article.
Pharmacological inhibition of SCD1 abrogates chemoresistance and tumor-initiating cell frequency. Clinically, high proteomic level of ADAR1 and SCD1, or high SCD1 editing/ADAR1 mRNA signature score predicts a worse prognosis. ...
Pharmacological inhibition of SCD1 abrogates chemoresistance and tumor-initiating cell frequency. Clinically, high proteomic level of …
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Zhu X, et al. Free Radic Biol Med. 2019 Sep;141:192-204. doi: 10.1016/j.freeradbiomed.2019.06.019. Epub 2019 Jun 18. Free Radic Biol Med. 2019. PMID: 31226399
Knockdown of SCD1 expression mimicked the effect of BBR decreasing TG level in steatotic hepatocytes, whereas overexpression of SCD1 attenuated the effect of BBR. ...Activation of the AMPK-SREBP-1c pathway and sterol regulatory element (SRE) motif in SCD1 pro …
Knockdown of SCD1 expression mimicked the effect of BBR decreasing TG level in steatotic hepatocytes, whereas overexpression of SC …
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.
Chen H, Qi Q, Wu N, Wang Y, Feng Q, Jin R, Jiang L. Chen H, et al. Redox Biol. 2022 Sep;55:102426. doi: 10.1016/j.redox.2022.102426. Epub 2022 Aug 4. Redox Biol. 2022. PMID: 35963119 Free PMC article.
Moreover, genetic ablation of SREBP-1 or SCD1 conferred cancer cells greater sensitivity to ferroptosis induction. Conversely, ectopic expression of SREBP-1 or SCD1 restored ferroptosis resistance in CRC cells and abolished the effect of aspirin on RSL3-induced cyto …
Moreover, genetic ablation of SREBP-1 or SCD1 conferred cancer cells greater sensitivity to ferroptosis induction. Conversely, ectopi …
An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming.
Liu HH, Xu Y, Li CJ, Hsu SJ, Lin XH, Zhang R, Chen J, Chen J, Gao DM, Cui JF, Yang XR, Ren ZG, Chen RX. Liu HH, et al. Mol Ther. 2022 Jul 6;30(7):2554-2567. doi: 10.1016/j.ymthe.2022.03.015. Epub 2022 Mar 28. Mol Ther. 2022. PMID: 35358687 Free PMC article.
The comparative lipidomic screening revealed that stearoyl-CoA desaturase 1 (SCD1) is a mechanoresponsive enzyme that reprogrammed HCC cell lipid metabolism. ...Knockdown of SCD1 suppressed HCC invasion and metastasis in vivo. Conversely, the overexpression of SC …
The comparative lipidomic screening revealed that stearoyl-CoA desaturase 1 (SCD1) is a mechanoresponsive enzyme that reprogrammed HC …
Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance.
Wu T, Wan J, Qu X, Xia K, Wang F, Zhang Z, Yang M, Wu X, Gao R, Yuan X, Fang L, Chen C, Yin L. Wu T, et al. Cell Death Dis. 2023 Mar 31;14(3):229. doi: 10.1038/s41419-023-05756-6. Cell Death Dis. 2023. PMID: 37002201 Free PMC article.
Mechanistically, SCD1 was transcriptionally up-regulated by Smad2/3 pathway activation in response to Nodal overexpression. Significant Nodal and SCD1 up-regulation were observed in CRC tissues and were associated with CRC metastasis and poor clinical outcomes. ...
Mechanistically, SCD1 was transcriptionally up-regulated by Smad2/3 pathway activation in response to Nodal overexpression. Significa …
Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence.
Luis G, Godfroid A, Nishiumi S, Cimino J, Blacher S, Maquoi E, Wery C, Collignon A, Longuespée R, Montero-Ruiz L, Dassoul I, Maloujahmoum N, Pottier C, Mazzucchelli G, Depauw E, Bellahcène A, Yoshida M, Noel A, Sounni NE. Luis G, et al. Redox Biol. 2021 Jul;43:102006. doi: 10.1016/j.redox.2021.102006. Epub 2021 May 14. Redox Biol. 2021. PMID: 34030117 Free PMC article.
SCD1 and FABP4 were also found upregulated in recurrent human breast cancer samples and correlated with worse prognosis of cancer patients with different types of tumors. Mechanistically, SCD1 leads to fatty acid (FA) desaturation and FABP4 derived from TEM enhances …
SCD1 and FABP4 were also found upregulated in recurrent human breast cancer samples and correlated with worse prognosis of cancer pat …
Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating beta-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody.
Katoh Y, Yaguchi T, Kubo A, Iwata T, Morii K, Kato D, Ohta S, Satomi R, Yamamoto Y, Oyamada Y, Ouchi K, Takahashi S, Ishioka C, Matoba R, Suematsu M, Kawakami Y. Katoh Y, et al. J Immunother Cancer. 2022 Jul;10(7):e004616. doi: 10.1136/jitc-2022-004616. J Immunother Cancer. 2022. PMID: 35793868 Free PMC article.
Administration of SCD1 inhibitor or SCD1 knockout in mice synergized with an anti-PD-1 antibody for its antitumor effects in mouse tumor models. High SCD1 expression was observed in one of the non-T cell-inflamed subtypes in human colon cancer, and serum S …
Administration of SCD1 inhibitor or SCD1 knockout in mice synergized with an anti-PD-1 antibody for its antitumor effects in m …
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Wohlhieter CA, Richards AL, Uddin F, Hulton CH, Quintanal-Villalonga À, Martin A, de Stanchina E, Bhanot U, Asher M, Shah NS, Hayatt O, Buonocore DJ, Rekhtman N, Shen R, Arbour KC, Donoghue M, Poirier JT, Sen T, Rudin CM. Wohlhieter CA, et al. Cell Rep. 2020 Dec 1;33(9):108444. doi: 10.1016/j.celrep.2020.108444. Cell Rep. 2020. PMID: 33264619 Free PMC article.
STK11/KEAP1 co-mutation results in significantly elevated expression of ferroptosis-protective genes, including SCD and AKR1C1/2/3, and resistance to pharmacologically induced ferroptosis. CRISPR screening further nominates SCD (SCD1) as selectively essential in STK11/KEAP …
STK11/KEAP1 co-mutation results in significantly elevated expression of ferroptosis-protective genes, including SCD and AKR1C1/2/3, and resi …
2,301 results