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Page 1
Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers.
Hardy GA, Sieg S, Rodriguez B, Anthony D, Asaad R, Jiang W, Mudd J, Schacker T, Funderburg NT, Pilch-Cooper HA, Debernardo R, Rabin RL, Lederman MM, Harding CV. Hardy GA, et al. Among authors: schacker t. PLoS One. 2013;8(2):e56527. doi: 10.1371/journal.pone.0056527. Epub 2013 Feb 20. PLoS One. 2013. PMID: 23437155 Free PMC article.
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.
Lima NS, Musayev M, Johnston TS, Wagner DA, Henry AR, Wang L, Yang ES, Zhang Y, Birungi K, Black WP, O'Dell S, Schmidt SD, Moon D, Lorang CG, Zhao B, Chen M, Boswell KL, Roberts-Torres J, Davis RL, Peyton L, Narpala SR, O'Connell S, Serebryannyy L, Wang J, Schrager A, Talana CA, Shimberg G, Leung K, Shi W, Khashab R, Biber A, Zilberman T, Rhein J, Vetter S, Ahmed A, Novik L, Widge A, Gordon I, Guech M, Teng IT, Phung E, Ruckwardt TJ, Pegu A, Misasi J, Doria-Rose NA, Gaudinski M, Koup RA, Kwong PD, McDermott AB, Amit S, Schacker TW, Levy I, Mascola JR, Sullivan NJ, Schramm CA, Douek DC. Lima NS, et al. Among authors: schacker tw. Nat Commun. 2022 Dec 14;13(1):7733. doi: 10.1038/s41467-022-35456-2. Nat Commun. 2022. PMID: 36517467 Free PMC article.
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC. Brenchley JM, et al. Nat Med. 2006 Dec;12(12):1365-71. doi: 10.1038/nm1511. Epub 2006 Nov 19. Nat Med. 2006. PMID: 17115046
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
Mudd JC, Murphy P, Manion M, Debernardo R, Hardacre J, Ammori J, Hardy GA, Harding CV, Mahabaleshwar GH, Jain MK, Jacobson JM, Brooks AD, Lewis S, Schacker TW, Anderson J, Haddad EK, Cubas RA, Rodriguez B, Sieg SF, Lederman MM. Mudd JC, et al. Blood. 2013 Apr 11;121(15):2914-22. doi: 10.1182/blood-2012-07-445783. Epub 2013 Feb 19. Blood. 2013. PMID: 23422746 Free PMC article.
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG. Hunt PW, et al. Among authors: schacker tw. Blood. 2013 Jun 6;121(23):4635-46. doi: 10.1182/blood-2012-06-436345. Epub 2013 Apr 15. Blood. 2013. PMID: 23589670 Free PMC article. Clinical Trial.
Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.
Shive CL, Mudd JC, Funderburg NT, Sieg SF, Kyi B, Bazdar DA, Mangioni D, Gori A, Jacobson JM, Brooks AD, Hardacre J, Ammori J, Estes JD, Schacker TW, Rodriguez B, Lederman MM. Shive CL, et al. Among authors: schacker tw. J Infect Dis. 2014 Aug 15;210(4):619-29. doi: 10.1093/infdis/jiu125. Epub 2014 Feb 28. J Infect Dis. 2014. PMID: 24585897 Free PMC article.
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.
Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. Younes SA, et al. J Clin Invest. 2016 Jul 1;126(7):2745-56. doi: 10.1172/JCI85996. Epub 2016 Jun 20. J Clin Invest. 2016. PMID: 27322062 Free PMC article.
A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?
Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. Lederman MM, et al. Pathog Immun. 2016 Spring;1(1):154-164. doi: 10.20411/pai.v1i1.133. Pathog Immun. 2016. PMID: 27668293 Free PMC article.
Lymphoid tissue fibrosis is associated with impaired vaccine responses.
Kityo C, Makamdop KN, Rothenberger M, Chipman JG, Hoskuldsson T, Beilman GJ, Grzywacz B, Mugyenyi P, Ssali F, Akondy RS, Anderson J, Schmidt TE, Reimann T, Callisto SP, Schoephoerster J, Schuster J, Muloma P, Ssengendo P, Moysi E, Petrovas C, Lanciotti R, Zhang L, Arévalo MT, Rodriguez B, Ross TM, Trautmann L, Sekaly RP, Lederman MM, Koup RA, Ahmed R, Reilly C, Douek DC, Schacker TW. Kityo C, et al. Among authors: schacker tw. J Clin Invest. 2018 Jul 2;128(7):2763-2773. doi: 10.1172/JCI97377. Epub 2018 May 21. J Clin Invest. 2018. PMID: 29781814 Free PMC article.
145 results