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FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B. Klein T, et al. Among authors: scharenberg m. J Med Chem. 2010 Dec 23;53(24):8627-41. doi: 10.1021/jm101011y. Epub 2010 Nov 24. J Med Chem. 2010. PMID: 21105658
A flow cytometry-based assay for screening FimH antagonists.
Scharenberg M, Abgottspon D, Cicek E, Jiang X, Schwardt O, Rabbani S, Ernst B. Scharenberg M, et al. Assay Drug Dev Technol. 2011 Oct;9(5):455-64. doi: 10.1089/adt.2010.0357. Epub 2011 Jun 15. Assay Drug Dev Technol. 2011. PMID: 21675870
Target Selectivity of FimH Antagonists.
Scharenberg M, Schwardt O, Rabbani S, Ernst B. Scharenberg M, et al. J Med Chem. 2012 Nov 26;55(22):9810-6. doi: 10.1021/jm3010338. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23088608
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.
Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B. Kleeb S, et al. Among authors: scharenberg m. J Med Chem. 2015 Mar 12;58(5):2221-39. doi: 10.1021/jm501524q. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25666045
Exploring host-pathogen interactions through genome wide protein microarray analysis.
Scietti L, Sampieri K, Pinzuti I, Bartolini E, Benucci B, Liguori A, Haag AF, Lo Surdo P, Pansegrau W, Nardi-Dei V, Santini L, Arora S, Leber X, Rindi S, Savino S, Costantino P, Maione D, Merola M, Speziale P, Bottomley MJ, Bagnoli F, Masignani V, Pizza M, Scharenberg M, Schlaeppi JM, Nissum M, Liberatori S. Scietti L, et al. Among authors: scharenberg m. Sci Rep. 2016 Jun 15;6:27996. doi: 10.1038/srep27996. Sci Rep. 2016. PMID: 27302108 Free PMC article.
Development of Anti-CD32b Antibodies with Enhanced Fc Function for the Treatment of B and Plasma Cell Malignancies.
Lu H, Molony RD, Chen D, Jang S, Wolf B, Ewert S, Flaherty M, Xu F, Isim S, Shim Y, Dornelas C, Balke N, Leber XC, Scharenberg M, Koelln J, Choi E, Ward R, Johnson J, Calzascia T, Isnardi I, Williams JA, Lindenbergh PL, van de Donk NWCJ, Mutis T, Huet H, Lees E, Meyer MJ. Lu H, et al. Among authors: scharenberg m. Mol Cancer Ther. 2020 Oct;19(10):2089-2104. doi: 10.1158/1535-7163.MCT-19-0003. Epub 2020 Aug 26. Mol Cancer Ther. 2020. PMID: 32847974
23 results