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A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.
Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE. Combs TP, et al. Among authors: scherer pe. Endocrinology. 2004 Jan;145(1):367-83. doi: 10.1210/en.2003-1068. Epub 2003 Oct 23. Endocrinology. 2004. PMID: 14576179
Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle.
Capozza F, Combs TP, Cohen AW, Cho YR, Park SY, Schubert W, Williams TM, Brasaemle DL, Jelicks LA, Scherer PE, Kim JK, Lisanti MP. Capozza F, et al. Among authors: scherer pe. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1317-31. doi: 10.1152/ajpcell.00489.2004. Epub 2005 Feb 2. Am J Physiol Cell Physiol. 2005. PMID: 15689413 Free article.
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment.
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF 3rd, Liotta L, Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE. Iyengar P, et al. Among authors: scherer pe. J Clin Invest. 2005 May;115(5):1163-76. doi: 10.1172/JCI23424. Epub 2005 Apr 14. J Clin Invest. 2005. PMID: 15841211 Free PMC article.
The adipocyte as an important target cell for Trypanosoma cruzi infection.
Combs TP, Nagajyothi, Mukherjee S, de Almeida CJ, Jelicks LA, Schubert W, Lin Y, Jayabalan DS, Zhao D, Braunstein VL, Landskroner-Eiger S, Cordero A, Factor SM, Weiss LM, Lisanti MP, Tanowitz HB, Scherer PE. Combs TP, et al. Among authors: scherer pe. J Biol Chem. 2005 Jun 24;280(25):24085-94. doi: 10.1074/jbc.M412802200. Epub 2005 Apr 18. J Biol Chem. 2005. PMID: 15843370 Free article.
Consuming fructose-sweetened beverages increases body adiposity in mice.
Jürgens H, Haass W, Castañeda TR, Schürmann A, Koebnick C, Dombrowski F, Otto B, Nawrocki AR, Scherer PE, Spranger J, Ristow M, Joost HG, Havel PJ, Tschöp MH. Jürgens H, et al. Among authors: scherer pe. Obes Res. 2005 Jul;13(7):1146-56. doi: 10.1038/oby.2005.136. Obes Res. 2005. PMID: 16076983 Free article.
Keynote review: the adipocyte as a drug discovery target.
Nawrocki AR, Scherer PE. Nawrocki AR, et al. Among authors: scherer pe. Drug Discov Today. 2005 Sep 15;10(18):1219-30. doi: 10.1016/S1359-6446(05)03569-5. Drug Discov Today. 2005. PMID: 16213414 Review.
515 results