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An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia.
Noda H, Guo J, Khatri A, Dean T, Reyes M, Armanini M, Brooks DJ, Martins JS, Schipani E, Bouxsein ML, Demay MB, Potts JT Jr, Jüppner H, Gardella TJ. Noda H, et al. Among authors: schipani e. J Bone Miner Res. 2020 Mar;35(3):540-549. doi: 10.1002/jbmr.3913. Epub 2019 Dec 4. J Bone Miner Res. 2020. PMID: 31693237 Free PMC article.
The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).
Jüppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT Jr, Kronenberg HM, Abou-Samra AB, Segre GV, Gardella TJ. Jüppner H, et al. Among authors: schipani e. Endocrinology. 1994 Feb;134(2):879-84. doi: 10.1210/endo.134.2.8299582. Endocrinology. 1994. PMID: 8299582
161 results