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A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer.
Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG. Delaney JR, et al. Among authors: schlaepfer dd. Oncotarget. 2015 Oct 13;6(31):31104-18. doi: 10.18632/oncotarget.5093. Oncotarget. 2015. PMID: 26418751 Free PMC article.
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG. Delaney JR, et al. Among authors: schlaepfer dd. Nat Commun. 2017 Feb 15;8:14423. doi: 10.1038/ncomms14423. Nat Commun. 2017. PMID: 28198375 Free PMC article.
FERM control of FAK function: implications for cancer therapy.
Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. Lim ST, et al. Among authors: schlaepfer dd. Cell Cycle. 2008 Aug;7(15):2306-14. doi: 10.4161/cc.6367. Epub 2008 May 29. Cell Cycle. 2008. PMID: 18677107 Free PMC article. Review.
Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.
Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD. Kleinschmidt EG, et al. Among authors: schlaepfer dd. Oncogene. 2019 Sep;38(36):6323-6337. doi: 10.1038/s41388-019-0881-8. Epub 2019 Jul 15. Oncogene. 2019. PMID: 31308489 Free PMC article.
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Győrffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Diaz Osterman CJ, et al. Among authors: schlaepfer dd. Elife. 2019 Sep 3;8:e47327. doi: 10.7554/eLife.47327. Elife. 2019. PMID: 31478830 Free PMC article.
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.
Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG. Delaney JR, et al. Among authors: schlaepfer dd. PLoS Genet. 2020 Jan 10;16(1):e1008558. doi: 10.1371/journal.pgen.1008558. eCollection 2020 Jan. PLoS Genet. 2020. PMID: 31923184 Free PMC article.
Targeting FAK in anticancer combination therapies.
Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC. Dawson JC, et al. Among authors: schlaepfer dd. Nat Rev Cancer. 2021 May;21(5):313-324. doi: 10.1038/s41568-021-00340-6. Epub 2021 Mar 17. Nat Rev Cancer. 2021. PMID: 33731845 Free PMC article. Review.
128 results