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Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Reed L, et al. Among authors: schmeiser hh. Toxicol Appl Pharmacol. 2019 Mar 1;366:64-74. doi: 10.1016/j.taap.2019.01.020. Epub 2019 Jan 25. Toxicol Appl Pharmacol. 2019. PMID: 30685480 Free PMC article.
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Stiborová M, Dracínská H, Mizerovská J, Frei E, Schmeiser HH, Hudecek J, Hodek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: schmeiser hh. Toxicology. 2008 May 2;247(1):11-22. doi: 10.1016/j.tox.2008.01.018. Epub 2008 Feb 6. Toxicology. 2008. PMID: 18329153
Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: schmeiser hh. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.
179 results