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Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.
Castro J, Garcia-Caraballo S, Maddern J, Schober G, Lumsden A, Harrington A, Schmiel S, Lindstrom B, Adams J, Brierley SM. Castro J, et al. Among authors: schmiel s. Pain. 2022 Jan 1;163(1):e72-e86. doi: 10.1097/j.pain.0000000000002314. Pain. 2022. PMID: 33863856 Free PMC article.
Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.
Robinson C, Baehr C, Schmiel SE, Accetturo C, Mueller DL, Pravetoni M. Robinson C, et al. Among authors: schmiel se. Hum Vaccin Immunother. 2019;15(4):909-917. doi: 10.1080/21645515.2018.1558697. Epub 2019 Feb 20. Hum Vaccin Immunother. 2019. PMID: 30625019 Free PMC article.
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.
Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL. Kalekar LA, et al. Among authors: schmiel se. Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1. Nat Immunol. 2016. PMID: 26829766 Free PMC article.