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Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.
White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A. White HS, et al. Among authors: schousboe a. J Pharmacol Exp Ther. 2002 Aug;302(2):636-44. doi: 10.1124/jpet.102.034819. J Pharmacol Exp Ther. 2002. PMID: 12130726
GABA transporters and GABA-transaminase as drug targets.
Sarup A, Larsson OM, Schousboe A. Sarup A, et al. Among authors: schousboe a. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):269-77. doi: 10.2174/1568007033482788. Curr Drug Targets CNS Neurol Disord. 2003. PMID: 12871037 Review.
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, Bolvig T, Petersen G, Larsson OM, Clausen RP, Frølund B, Falch E, Krogsgaard-Larsen P, Schousboe A. White HS, et al. Among authors: schousboe a. J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. doi: 10.1124/jpet.104.068825. Epub 2004 Nov 18. J Pharmacol Exp Ther. 2005. PMID: 15550575
537 results