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A molecular tweezer for lysine and arginine.
Fokkens M, Schrader T, Klärner FG. Fokkens M, et al. Among authors: schrader t. J Am Chem Soc. 2005 Oct 19;127(41):14415-21. doi: 10.1021/ja052806a. J Am Chem Soc. 2005. PMID: 16218636
A mechanism of efficient G6PD inhibition by a molecular clip.
Kirsch M, Talbiersky P, Polkowska J, Bastkowski F, Schaller T, de Groot H, Klärner FG, Schrader T. Kirsch M, et al. Among authors: schrader t. Angew Chem Int Ed Engl. 2009;48(16):2886-90. doi: 10.1002/anie.200806175. Angew Chem Int Ed Engl. 2009. PMID: 19283805
Rational design of β-sheet ligands against Aβ42-induced toxicity.
Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. Hochdörffer K, et al. Among authors: schrader t. J Am Chem Soc. 2011 Mar 30;133(12):4348-58. doi: 10.1021/ja107675n. Epub 2011 Mar 7. J Am Chem Soc. 2011. PMID: 21381732
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: schrader t. J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29. J Am Chem Soc. 2011. PMID: 21916458 Free PMC article.
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. Prabhudesai S, et al. Among authors: schrader t. Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Neurotherapeutics. 2012. PMID: 22373667 Free PMC article.
339 results