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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
Qiao S, Langlois CR, Chrustowicz J, Sherpa D, Karayel O, Hansen FM, Beier V, von Gronau S, Bollschweiler D, Schäfer T, Alpi AF, Mann M, Prabu JR, Schulman BA. Qiao S, et al. Among authors: schulman ba. Mol Cell. 2020 Jan 2;77(1):150-163.e9. doi: 10.1016/j.molcel.2019.10.009. Epub 2019 Nov 7. Mol Cell. 2020. PMID: 31708416 Free article.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. Baek K, et al. Among authors: schulman ba. Nature. 2020 Feb;578(7795):461-466. doi: 10.1038/s41586-020-2000-y. Epub 2020 Feb 12. Nature. 2020. PMID: 32051583 Free PMC article.
Quantifying the heterogeneity of macromolecular machines by mass photometry.
Sonn-Segev A, Belacic K, Bodrug T, Young G, VanderLinden RT, Schulman BA, Schimpf J, Friedrich T, Dip PV, Schwartz TU, Bauer B, Peters JM, Struwe WB, Benesch JLP, Brown NG, Haselbach D, Kukura P. Sonn-Segev A, et al. Among authors: schulman ba. Nat Commun. 2020 Apr 14;11(1):1772. doi: 10.1038/s41467-020-15642-w. Nat Commun. 2020. PMID: 32286308 Free PMC article.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA. Liwocha J, et al. Among authors: schulman ba. Nat Chem Biol. 2021 Mar;17(3):272-279. doi: 10.1038/s41589-020-00696-0. Epub 2020 Dec 7. Nat Chem Biol. 2021. PMID: 33288957 Free PMC article.
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Horn-Ghetko D, et al. Among authors: schulman ba. Nature. 2021 Feb;590(7847):671-676. doi: 10.1038/s41586-021-03197-9. Epub 2021 Feb 3. Nature. 2021. PMID: 33536622 Free PMC article.
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Sherpa D, Chrustowicz J, Qiao S, Langlois CR, Hehl LA, Gottemukkala KV, Hansen FM, Karayel O, von Gronau S, Prabu JR, Mann M, Alpi AF, Schulman BA. Sherpa D, et al. Among authors: schulman ba. Mol Cell. 2021 Jun 3;81(11):2445-2459.e13. doi: 10.1016/j.molcel.2021.03.025. Epub 2021 Apr 26. Mol Cell. 2021. PMID: 33905682 Free PMC article.
199 results