Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes.
Okamato Y, Ghosh T, Okamoto T, Schuyler RP, Seifert J, Charry LL, Visser A, Feser M, Fleischer C, Pedrick C, August J, Moss L, Bemis EA, Norris JM, Kuhn KA, Demoruelle MK, Deane KD, Ghosh D, Holers VM, Hsieh EWY.
Okamato Y, et al.
J Autoimmun. 2021 Feb;117:102581. doi: 10.1016/j.jaut.2020.102581. Epub 2020 Dec 9.
J Autoimmun. 2021.
PMID: 33310262
Free PMC article.
Taken together, dysregulated PAD4-driven cytokine production as well as MET formation in CD14(hi) monocytes in ACPA (+) at-risk subjects likely plays an important role in the development of RA via promoting and perpetuating inflammation and generation of citrullinated auto …
Taken together, dysregulated PAD4-driven cytokine production as well as MET formation in CD14(hi) monocytes in ACPA (+) at-risk subje …