Segura-Aguilar J - Search Results

1

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?

Herrera A, Muñoz P, Steinbusch HWM, Segura-Aguilar J. Herrera A, et al. ACS Chem Neurosci. 2017 Apr 19;8(4):702-711. doi: 10.1021/acschemneuro.7b00034. Epub 2017 Mar 3. ACS Chem Neurosci. 2017. PMID: 28233992 Review.

2

Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.

Graumann R, Paris I, Martinez-Alvarado P, Rumanque P, Perez-Pastene C, Cardenas SP, Marin P, Diaz-Grez F, Caviedes R, Caviedes P, Segura-Aguilar J. Graumann R, et al. Pol J Pharmacol. 2002 Nov-Dec;54(6):573-9. Pol J Pharmacol. 2002. PMID: 12866711 Free article. Review.

3

On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.

Arriagada C, Paris I, Sanchez de las Matas MJ, Martinez-Alvarado P, Cardenas S, Castañeda P, Graumann R, Perez-Pastene C, Olea-Azar C, Couve E, Herrero MT, Caviedes P, Segura-Aguilar J. Arriagada C, et al. Neurobiol Dis. 2004 Jul;16(2):468-77. doi: 10.1016/j.nbd.2004.03.014. Neurobiol Dis. 2004. PMID: 15193303

4

Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component.

Perez-Pastene C, Graumann R, Díaz-Grez F, Miranda M, Venegas P, Godoy OT, Layson L, Villagra R, Matamala JM, Herrera L, Segura-Aguilar J. Perez-Pastene C, et al. Neurosci Lett. 2007 May 17;418(2):181-5. doi: 10.1016/j.neulet.2007.03.024. Epub 2007 Mar 14. Neurosci Lett. 2007. PMID: 17403576

5

Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease.

Paris I, Cardenas S, Lozano J, Perez-Pastene C, Graumann R, Riveros A, Caviedes P, Segura-Aguilar J. Paris I, et al. Neurotox Res. 2007 Sep;12(2):125-34. doi: 10.1007/BF03033921. Neurotox Res. 2007. PMID: 17967736 Review.

6

Molecular and neurochemical mechanisms in PD pathogenesis.

Paris I, Lozano J, Perez-Pastene C, Muñoz P, Segura-Aguilar J. Paris I, et al. Neurotox Res. 2009 Oct;16(3):271-9. doi: 10.1007/s12640-009-9059-4. Epub 2009 May 20. Neurotox Res. 2009. PMID: 19526278

7

Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks in substantia-nigra-derived cell line.

Paris I, Perez-Pastene C, Cardenas S, Iturriaga-Vasquez P, Muñoz P, Couve E, Caviedes P, Segura-Aguilar J. Paris I, et al. Neurotox Res. 2010 Jul;18(1):82-92. doi: 10.1007/s12640-009-9148-4. Epub 2010 Jan 20. Neurotox Res. 2010. PMID: 20087799

8

Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity.

Lozano J, Muñoz P, Nore BF, Ledoux S, Segura-Aguilar J. Lozano J, et al. Chem Res Toxicol. 2010 Sep 20;23(9):1492-6. doi: 10.1021/tx100182a. Chem Res Toxicol. 2010. PMID: 20849151

9

Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.

Paris I, Muñoz P, Huenchuguala S, Couve E, Sanders LH, Greenamyre JT, Caviedes P, Segura-Aguilar J. Paris I, et al. Toxicol Sci. 2011 Jun;121(2):376-88. doi: 10.1093/toxsci/kfr060. Epub 2011 Apr 6. Toxicol Sci. 2011. PMID: 21427056 Free PMC article.

10

Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.

Muñoz P, Paris I, Sanders LH, Greenamyre JT, Segura-Aguilar J. Muñoz P, et al. Biochim Biophys Acta. 2012 Jul;1822(7):1125-36. doi: 10.1016/j.bbadis.2012.03.010. Epub 2012 Mar 27. Biochim Biophys Acta. 2012. PMID: 22483869 Free PMC article.

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