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Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.
Ugleholdt R, Pedersen J, Bassi MR, Füchtbauer EM, Jørgensen SM, Kissow HL, Nytofte N, Poulsen SS, Rosenkilde MM, Seino Y, Thams P, Holst PJ, Holst JJ. Ugleholdt R, et al. Among authors: seino y. J Biol Chem. 2011 Dec 30;286(52):44632-45. doi: 10.1074/jbc.M111.311779. Epub 2011 Oct 25. J Biol Chem. 2011. PMID: 22027838 Free PMC article.
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, Seino Y. Miyawaki K, et al. Among authors: seino y. Nat Med. 2002 Jul;8(7):738-42. doi: 10.1038/nm727. Epub 2002 Jun 17. Nat Med. 2002. PMID: 12068290
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.
Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y. Yabe D, et al. Among authors: seino y. J Diabetes Complications. 2015 Apr;29(3):413-21. doi: 10.1016/j.jdiacomp.2014.12.010. Epub 2014 Dec 26. J Diabetes Complications. 2015. PMID: 25613093 Free article. Clinical Trial.
1,474 results