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Page 1
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Elife. 2019 Feb 12;8:e40811. doi: 10.7554/eLife.40811.
Elife. 2019.
PMID: 30747709
Free PMC article.
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW.
Sun S, et al. Among authors: tokunaga s.
Nat Commun. 2015 Jan 27;6:6171. doi: 10.1038/ncomms7171.
Nat Commun. 2015.
PMID: 25625564
Free PMC article.
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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.
Ling SC, et al. Among authors: tokunaga s.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13318-23. doi: 10.1073/pnas.1008227107. Epub 2010 Jul 12.
Proc Natl Acad Sci U S A. 2010.
PMID: 20624952
Free PMC article.
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Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.
Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW.
Sun S, et al. Among authors: tokunaga s.
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6993-7002. doi: 10.1073/pnas.1520639112. Epub 2015 Nov 30.
Proc Natl Acad Sci U S A. 2015.
PMID: 26621731
Free PMC article.
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Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.
Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR.
Cortes CJ, et al. Among authors: tokunaga s.
Neuron. 2014 Apr 16;82(2):295-307. doi: 10.1016/j.neuron.2014.03.001.
Neuron. 2014.
PMID: 24742458
Free PMC article.
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