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Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae).
El-Saber Batiha G, Magdy Beshbishy A, El-Mleeh A, Abdel-Daim MM, Prasad Devkota H. El-Saber Batiha G, et al. Biomolecules. 2020 Feb 25;10(3):352. doi: 10.3390/biom10030352. Biomolecules. 2020. PMID: 32106571 Free PMC article. Review.
Moreover, chemical analysis of the G. glabra extracts revealed the presence of several organic acids, liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, 1-metho-xyphaseolin, shinpterocarpin, shinflavanone, licopyranocoumarin, glisoflavone, …
Moreover, chemical analysis of the G. glabra extracts revealed the presence of several organic acids, liquirtin, rhamnoliquirilin, liquiriti …
Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling.
Hsieh MJ, Ho HY, Lo YS, Lin CC, Chuang YC, Abomughaid MM, Hsieh MC, Chen MK. Hsieh MJ, et al. Int J Mol Sci. 2023 Feb 24;24(5):4505. doi: 10.3390/ijms24054505. Int J Mol Sci. 2023. PMID: 36901935 Free PMC article.
The present study aimed to investigate the anticancer activities of semilicoisoflavone B (SFB), which is a natural phenolic compound isolated from Glycyrrhiza species. ...
The present study aimed to investigate the anticancer activities of semilicoisoflavone B (SFB), which is a natural phenolic co …
Semilicoisoflavone B induces oral cancer cell apoptosis by targeting claspin and ATR-Chk1 signaling pathways.
Hsieh MJ, Lin CC, Lo YS, Chuang YC, Ho HY, Chen MK. Hsieh MJ, et al. Environ Toxicol. 2024 Apr;39(4):2417-2428. doi: 10.1002/tox.24107. Epub 2024 Jan 10. Environ Toxicol. 2024. PMID: 38197544
The present study was designed to investigate the anticancer effect and mode of action of Glycyrrhiza-derived semilicoisoflavone B (SFB) in 5-fluorourasil (5FU)-resistant human OSCC cell lines. ...
The present study was designed to investigate the anticancer effect and mode of action of Glycyrrhiza-derived semilicoisoflavone B …
Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Abeta Secretion by Increasing PPARgamma Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression.
Gu MY, Chun YS, Zhao D, Ryu SY, Yang HO. Gu MY, et al. Mol Nutr Food Res. 2018 Mar;62(6):e1700633. doi: 10.1002/mnfr.201700633. Epub 2018 Feb 23. Mol Nutr Food Res. 2018. PMID: 29143445
Therefore, decreasing Abeta levels is one strategy for preventing the etiology of AD. This study aims to test the effect of GUE and semilicoisoflavone B (SB) on Abeta secretion and investigates the mechanism underlying this effect. ...
Therefore, decreasing Abeta levels is one strategy for preventing the etiology of AD. This study aims to test the effect of GUE and semil …
Metabolites identification of bioactive licorice compounds in rats.
Wang Q, Qian Y, Wang Q, Yang YF, Ji S, Song W, Qiao X, Guo DA, Liang H, Ye M. Wang Q, et al. J Pharm Biomed Anal. 2015 Nov 10;115:515-22. doi: 10.1016/j.jpba.2015.08.013. Epub 2015 Aug 17. J Pharm Biomed Anal. 2015. PMID: 26311472
These compounds include 22beta-acetoxyl glycyrrhizin (1), licoflavonol (2), licoricidin (3), licoisoflavanone (4), isoglycycoumarin (5), semilicoisoflavone B (6), and 3-methoxy-9-hydroxy-pterocarpan (7). After oral administration of 250mg/kg of 1 or 40mg/kg of 2-7 t …
These compounds include 22beta-acetoxyl glycyrrhizin (1), licoflavonol (2), licoricidin (3), licoisoflavanone (4), isoglycycoumarin (5), …
Licoflavonol Reduces Aβ Secretion by Increasing BACE1 Phosphorylation to Facilitate BACE1 Degradation.
Gu MY, Chun YS, Yong RS, Yang HO. Gu MY, et al. Mol Nutr Food Res. 2019 Feb;63(3):e1800474. doi: 10.1002/mnfr.201800474. Epub 2019 Jan 11. Mol Nutr Food Res. 2019. PMID: 30365228
SCOPE: In the previous study, Glycyrrhiza uralensis Fisch extract (GUE) inhibited Abeta secretion by inhibiting beta-site APP-cleaving enzyme 1 (BACE1) transcription, and the active compounds semilicoisoflavone B (SB) and licoflavonol (LF) inhibited Abeta secretion. …
SCOPE: In the previous study, Glycyrrhiza uralensis Fisch extract (GUE) inhibited Abeta secretion by inhibiting beta-site APP-cleaving enzym …
Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.
Lee YS, Kim SH, Jung SH, Kim JK, Pan CH, Lim SS. Lee YS, et al. Biol Pharm Bull. 2010;33(5):917-21. doi: 10.1248/bpb.33.917. Biol Pharm Bull. 2010. PMID: 20460778 Free article.
The anti-diabetic complication activities of 10 G. uralensis-derived components were investigated via inhibitory assays using rat lens AR (rAR) and human recombinant AR (rhAR). From the 10 isolated compounds, semilicoisoflavone B showed the most potent inhibition, w …
The anti-diabetic complication activities of 10 G. uralensis-derived components were investigated via inhibitory assays using rat lens AR (r …
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
Lin Y, Kuang Y, Li K, Wang S, Song W, Qiao X, Sabir G, Ye M. Lin Y, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3706-3713. doi: 10.1016/j.bmc.2017.05.009. Epub 2017 May 6. Bioorg Med Chem. 2017. PMID: 28522265
Particularly, licoagrochalcone A (4), kanzonol C (7), 2'-hydroxyisolupalbigenin (35), gancaonin Q (45), glisoflavanone (50) and glabrol (53) showed IC(50) values of 0.31-0.97muM. Compounds 24 (semilicoisoflavone B, IC(50) 0.25muM), 26 (allolicoisoflavone B, IC(50) 0 …
Particularly, licoagrochalcone A (4), kanzonol C (7), 2'-hydroxyisolupalbigenin (35), gancaonin Q (45), glisoflavanone (50) and glabrol (53) …