Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1931 1
1938 1
1944 2
1945 8
1946 10
1947 10
1948 7
1949 14
1950 14
1951 17
1952 18
1953 22
1954 28
1955 46
1956 31
1957 40
1958 36
1959 41
1960 46
1961 35
1962 69
1963 99
1964 204
1965 111
1966 87
1967 96
1968 125
1969 111
1970 113
1971 127
1972 143
1973 138
1974 141
1975 380
1976 415
1977 392
1978 378
1979 384
1980 433
1981 481
1982 514
1983 624
1984 698
1985 756
1986 854
1987 1019
1988 1077
1989 1229
1990 1394
1991 1657
1992 1752
1993 2018
1994 2186
1995 2297
1996 2353
1997 2374
1998 2538
1999 2654
2000 2782
2001 2784
2002 2888
2003 3032
2004 3232
2005 3361
2006 3507
2007 3579
2008 3553
2009 3622
2010 3948
2011 4081
2012 4114
2013 4141
2014 4090
2015 4000
2016 3974
2017 4047
2018 4178
2019 4137
2020 4775
2021 5038
2022 4736
2023 4435
2024 1754

Text availability

Article attribute

Article type

Publication date

Search Results

116,337 results

Results by year

Filters applied: . Clear all
Page 1
Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis.
Shan X, Hu P, Ni L, Shen L, Zhang Y, Ji Z, Cui Y, Guo M, Wang H, Ran L, Yang K, Wang T, Wang L, Chen B, Yao Z, Wu Y, Yu Q. Shan X, et al. Cell Mol Immunol. 2022 Nov;19(11):1263-1278. doi: 10.1038/s41423-022-00925-7. Epub 2022 Sep 30. Cell Mol Immunol. 2022. PMID: 36180780 Free PMC article.
Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key e …
Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage …
Serine and glycine metabolism in cancer.
Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G. Amelio I, et al. Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20. Trends Biochem Sci. 2014. PMID: 24657017 Free PMC article. Review.
Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. ...The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the …
Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. ...The import …
Serine and one-carbon metabolism in cancer.
Yang M, Vousden KH. Yang M, et al. Nat Rev Cancer. 2016 Oct;16(10):650-62. doi: 10.1038/nrc.2016.81. Epub 2016 Sep 16. Nat Rev Cancer. 2016. PMID: 27634448 Review.
As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence. Many cancer cells are highly dependent on serine, a trait that provides several novel therape …
As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the gener …
Serine Metabolism Supports Macrophage IL-1beta Production.
Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Rodriguez AE, et al. Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. doi: 10.1016/j.cmet.2019.01.014. Epub 2019 Feb 14. Cell Metab. 2019. PMID: 30773464 Free PMC article.
Serine is a substrate for nucleotide, NADPH, and glutathione (GSH) synthesis. ...Our study reveals that serine metabolism is necessary for GSH synthesis to support IL-1beta cytokine production....
Serine is a substrate for nucleotide, NADPH, and glutathione (GSH) synthesis. ...Our study reveals that serine metabolism is n …
The ins and outs of serine and glycine metabolism in cancer.
Geeraerts SL, Heylen E, De Keersmaecker K, Kampen KR. Geeraerts SL, et al. Nat Metab. 2021 Feb;3(2):131-141. doi: 10.1038/s42255-020-00329-9. Epub 2021 Jan 28. Nat Metab. 2021. PMID: 33510397 Review.
Copy-number amplifications of serine- and glycine-synthesis genes and genetic alterations in common oncogenes and tumour-suppressor genes enhance serine and glycine synthesis, resulting in high production and secretion of these oncogenesis-supportive metabolites. .. …
Copy-number amplifications of serine- and glycine-synthesis genes and genetic alterations in common oncogenes and tumour-suppressor g …
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. Handzlik MK, et al. Nature. 2023 Feb;614(7946):118-124. doi: 10.1038/s41586-022-05637-6. Epub 2023 Jan 25. Nature. 2023. PMID: 36697822 Free PMC article.
Here we demonstrate that aberrant serine homeostasis drives serine and glycine deficiencies in diabetic mice, which can be diagnosed with a serine tolerance test that quantifies serine uptake and disposal. ...Normalization of serine by dietary s …
Here we demonstrate that aberrant serine homeostasis drives serine and glycine deficiencies in diabetic mice, which can be dia …
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.
Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C. Wang K, et al. Nat Commun. 2023 Feb 23;14(1):1011. doi: 10.1038/s41467-023-36708-5. Nat Commun. 2023. PMID: 36823188 Free PMC article.
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. ...PRMT1-mediated PHGDH methylation and activation potentiates serine synthesis, ameliorates oxidative stress, and promotes HCC growth in vitro and in …
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. ...PRMT1-mediated …
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. Yang L, et al. Cell Metab. 2020 Apr 7;31(4):809-821.e6. doi: 10.1016/j.cmet.2020.02.017. Epub 2020 Mar 17. Cell Metab. 2020. PMID: 32187526 Free PMC article.
In mice with engineered mitochondrial complex I deficiency (NDUSF4-/-), serine's contribution to NADH is elevated, and progression of spasticity is modestly slowed by pharmacological blockade of serine degradation. Thus, when respiration is impaired, serine c …
In mice with engineered mitochondrial complex I deficiency (NDUSF4-/-), serine's contribution to NADH is elevated, and progression of …
SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis.
Pranzini E, Pardella E, Muccillo L, Leo A, Nesi I, Santi A, Parri M, Zhang T, Uribe AH, Lottini T, Sabatino L, Caselli A, Arcangeli A, Raugei G, Colantuoni V, Cirri P, Chiarugi P, Maddocks ODK, Paoli P, Taddei ML. Pranzini E, et al. Cell Rep. 2022 Aug 16;40(7):111233. doi: 10.1016/j.celrep.2022.111233. Cell Rep. 2022. PMID: 35977477 Free article.
In particular, 5-FU-resistant CRC cells display a strong serine dependency achieved either by upregulating endogenous serine synthesis or increasing exogenous serine uptake. ...Interfering with serine availability or affecting its mitochondrial metabol …
In particular, 5-FU-resistant CRC cells display a strong serine dependency achieved either by upregulating endogenous serine s …
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG. Ma EH, et al. Cell Metab. 2017 Feb 7;25(2):345-357. doi: 10.1016/j.cmet.2016.12.011. Epub 2017 Jan 19. Cell Metab. 2017. PMID: 28111214 Free article.
Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregulate enzymes of the serine, glycine, one-carbon (SGOC) metabolic network, and rapidly increase processing of serine into one-ca …
Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregul …
116,337 results
You have reached the last available page of results. Please see the User Guide for more information.