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Kallistatin/Serpina3c inhibits cardiac fibrosis after myocardial infarction by regulating glycolysis via Nr4a1 activation.
Ji JJ, Qian LL, Zhu Y, Jiang Y, Guo JQ, Wu Y, Yang ZW, Yao YY, Ma GS. Ji JJ, et al. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166441. doi: 10.1016/j.bbadis.2022.166441. Epub 2022 May 14. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35577178 Free article.
Serpina3c expression decreased in MI hearts and CFs. Serpina3c(-/-) led to the aggravation of MI fibrosis, and increased the proliferation of CFs. The overexpression of Serpina3c in CFs had the opposite effect. Glycolysis-related genes were significantly incr …
Serpina3c expression decreased in MI hearts and CFs. Serpina3c(-/-) led to the aggravation of MI fibrosis, and increased the p …
SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
Li BY, Guo YY, Xiao G, Guo L, Tang QQ. Li BY, et al. Mol Metab. 2022 Jul;61:101500. doi: 10.1016/j.molmet.2022.101500. Epub 2022 Apr 15. Mol Metab. 2022. PMID: 35436587 Free PMC article.
METHODS: Male wild type (WT) and knockout (KO) mice were fed with high-fat diet (HFD) for 16 weeks, adiposity, insulin resistance, and inflammation were assessed. AAV-mediated overexpression of SERPINA3C was injected locally in inguinal white adipose tissue (iWAT) to exami …
METHODS: Male wild type (WT) and knockout (KO) mice were fed with high-fat diet (HFD) for 16 weeks, adiposity, insulin resistance, and infla …
Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through beta-catenin/Foxo1/TLR4 signaling.
Qian LL, Ji JJ, Jiang Y, Guo JQ, Wu Y, Yang Z, Ma GS, Yao YY. Qian LL, et al. FASEB J. 2022 May;36(5):e22316. doi: 10.1096/fj.202101345RRR. FASEB J. 2022. PMID: 35429042
The aim of this study was to determine the precise role of serpina3c in the process of NAFLD. Male Apoe(-/-) /serpina3c(-/-) double knockout (DKO) and Apoe(-/-) mice were fed a high-fat diet (HFD) for 12 weeks. ...Notably, serpina3c deficiency increased beta- …
The aim of this study was to determine the precise role of serpina3c in the process of NAFLD. Male Apoe(-/-) /serpina3c(-/-) d …
The versatile role of Serpina3c in physiological and pathological processes: a review of recent studies.
Li Y, Guo L. Li Y, et al. Front Endocrinol (Lausanne). 2023 May 23;14:1189007. doi: 10.3389/fendo.2023.1189007. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37288300 Free PMC article. Review.
Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. ...In addition, Serpina3c can improve atherosclerosis and regulate cardiac remodeling after myocardial infarction. ...
Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. ...In addition, Serpina3c …
Serpina3c regulates adipose differentiation via the Wnt/beta-catenin-PPARgamma pathway.
Guo J, Qian L, Ji J, Ji Z, Jiang Y, Wu Y, Yang Z, Ma G, Yao Y. Guo J, et al. Cell Signal. 2022 May;93:110299. doi: 10.1016/j.cellsig.2022.110299. Epub 2022 Mar 6. Cell Signal. 2022. PMID: 35263629
OBJECTIVE: The Serpin protein family plays an important role in regulating the functioning of the adipose tissue. This study aimed to study the underlying mechanisms of Serpina3c in regulating adipogenesis. METHODS: We developed a Serpina3c knockout (Serpina3c …
OBJECTIVE: The Serpin protein family plays an important role in regulating the functioning of the adipose tissue. This study aimed to study …
Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway.
Ji JJ, Qian LL, Zhu Y, Wu YP, Guo JQ, Ma GS, Yao YY. Ji JJ, et al. Cell Signal. 2020 Nov;75:109745. doi: 10.1016/j.cellsig.2020.109745. Epub 2020 Aug 20. Cell Signal. 2020. PMID: 32828866
BACKGROUND: Serpina3 is a member of the serine protease inhibitor family and is involved in the inflammatory response. In this study, we investigated the effect of Serpina3c on pancreatic function in hypercholesterolemic mice. METHODS: To investigate the role of Serpina …
BACKGROUND: Serpina3 is a member of the serine protease inhibitor family and is involved in the inflammatory response. In this study, we inv …
Serpina3c Regulates Adipogenesis by Modulating Insulin Growth Factor 1 and Integrin Signaling.
Choi Y, Choi H, Yoon BK, Lee H, Seok JW, Kim HJ, Kim JW. Choi Y, et al. iScience. 2020 Mar 27;23(3):100961. doi: 10.1016/j.isci.2020.100961. Epub 2020 Mar 4. iScience. 2020. PMID: 32193145 Free PMC article.
Serpina3c is a secretory protein and is highly expressed in fat tissues. Knockdown of Serpina3c decreased adipogenesis by attenuating the mitotic clonal expansion of 3T3-L1 cells. ...
Serpina3c is a secretory protein and is highly expressed in fat tissues. Knockdown of Serpina3c decreased adipogenesis by atte …
Protective role of serpina3c as a novel thrombin inhibitor against atherosclerosis in mice.
Qian LL, Ji JJ, Guo JQ, Wu YP, Ma GS, Yao YY. Qian LL, et al. Clin Sci (Lond). 2021 Feb 12;135(3):447-463. doi: 10.1042/CS20201235. Clin Sci (Lond). 2021. PMID: 33458764
An Apoe-/-/serpina3c-/--double-knockout mouse model was used to determine the role of serpina3c in atherosclerosis after HFD for 12 weeks. ...Moreover, an in vitro study confirmed that thrombin activity was also decreased by serpina3c protein, supernatant and …
An Apoe-/-/serpina3c-/--double-knockout mouse model was used to determine the role of serpina3c in atherosclerosis after HFD f …
Transient response of serpinA3 during cellular stress.
Sánchez-Navarro A, Murillo-de-Ozores AR, Pérez-Villalva R, Linares N, Carbajal-Contreras H, Flores ME, Gamba G, Castañeda-Bueno M, Bobadilla NA. Sánchez-Navarro A, et al. FASEB J. 2022 Mar;36(3):e22190. doi: 10.1096/fj.202101912R. FASEB J. 2022. PMID: 35147994
HEK-293 cells were transfected with a FLAG-tagged serpinA3c/k clone and exposed to H(2) O(2) or starvation. Both stressors induced serpinA3c/k secretion but with a higher molecular weight. ...During cellular stress, serpinA3c/k secretion increased with each m …
HEK-293 cells were transfected with a FLAG-tagged serpinA3c/k clone and exposed to H(2) O(2) or starvation. Both stressors induced …
Mechanism of hydroxysafflor yellow A on acute liver injury based on transcriptomics.
Hou X, Zhang Z, Ma Y, Jin R, Yi B, Yang D, Ma L. Hou X, et al. Front Pharmacol. 2022 Sep 2;13:966759. doi: 10.3389/fphar.2022.966759. eCollection 2022. Front Pharmacol. 2022. PMID: 36120318 Free PMC article.
Results: Relative to the control and HSYA groups, in the model group, we found 1111 DEGs that were up-/down-regulated, six of these genes were verified by qRT-PCR, including Tymp, Fabp7, Serpina3c, Gpnmb, Il1r1, and Creld2, indicated that these genes were obviously involve …
Results: Relative to the control and HSYA groups, in the model group, we found 1111 DEGs that were up-/down-regulated, six of these genes we …
22 results