Settleman J - Search Results

1

The complexity of targeting EGFR signalling in cancer: from expression to turnover.

Sebastian S, Settleman J, Reshkin SJ, Azzariti A, Bellizzi A, Paradiso A. Sebastian S, et al. Among authors: settleman j. Biochim Biophys Acta. 2006 Aug;1766(1):120-39. doi: 10.1016/j.bbcan.2006.06.001. Epub 2006 Jun 23. Biochim Biophys Acta. 2006. PMID: 16889899 Review.

2

Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.

Haber DA, Bell DW, Sordella R, Kwak EL, Godin-Heymann N, Sharma SV, Lynch TJ, Settleman J. Haber DA, et al. Among authors: settleman j. Cold Spring Harb Symp Quant Biol. 2005;70:419-26. doi: 10.1101/sqb.2005.70.043. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869779 Review.

3

Targeting the RAF-MEK-ERK pathway in cancer therapy.

Montagut C, Settleman J. Montagut C, et al. Among authors: settleman j. Cancer Lett. 2009 Oct 8;283(2):125-34. doi: 10.1016/j.canlet.2009.01.022. Epub 2009 Feb 12. Cancer Lett. 2009. PMID: 19217204 Review.

4

Detection of mutations in EGFR in circulating lung-cancer cells.

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA. Maheswaran S, et al. Among authors: settleman j. N Engl J Med. 2008 Jul 24;359(4):366-77. doi: 10.1056/NEJMoa0800668. Epub 2008 Jul 2. N Engl J Med. 2008. PMID: 18596266 Free PMC article.

5

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.

Marcar L, Bardhan K, Gheorghiu L, Dinkelborg P, Pfäffle H, Liu Q, Wang M, Piotrowska Z, Sequist LV, Borgmann K, Settleman JE, Engelman JA, Hata AN, Willers H. Marcar L, et al. Cell Rep. 2019 Jun 18;27(12):3422-3432.e4. doi: 10.1016/j.celrep.2019.05.058. Cell Rep. 2019. PMID: 31216465 Free PMC article.

6

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

Bell DW, Gore I, Okimoto RA, Godin-Heymann N, Sordella R, Mulloy R, Sharma SV, Brannigan BW, Mohapatra G, Settleman J, Haber DA. Bell DW, et al. Among authors: settleman j. Nat Genet. 2005 Dec;37(12):1315-6. doi: 10.1038/ng1671. Epub 2005 Oct 30. Nat Genet. 2005. PMID: 16258541

7

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.

McDermott U, Sharma SV, Settleman J. McDermott U, et al. Among authors: settleman j. Methods Enzymol. 2008;438:331-41. doi: 10.1016/S0076-6879(07)38023-3. Methods Enzymol. 2008. PMID: 18413259

8

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.

Sordella R, Bell DW, Haber DA, Settleman J. Sordella R, et al. Among authors: settleman j. Science. 2004 Aug 20;305(5687):1163-7. doi: 10.1126/science.1101637. Epub 2004 Jul 29. Science. 2004. PMID: 15284455

9

First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.

Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Jänne PA, Joshi VA, McCollum D, Evans TL, Muzikansky A, Kuhlmann GL, Han M, Goldberg JS, Settleman J, Iafrate AJ, Engelman JA, Haber DA, Johnson BE, Lynch TJ. Sequist LV, et al. Among authors: settleman j. J Clin Oncol. 2008 May 20;26(15):2442-9. doi: 10.1200/JCO.2007.14.8494. Epub 2008 May 5. J Clin Oncol. 2008. PMID: 18458038 Clinical Trial.

10

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors.

Chin TM, Boopathy GTK, Man EPS, Clohessy JG, Csizmadia E, Quinlan MP, Putti T, Wan SC, Xie C, Ali A, Wai FC, Ong YS, Goh BC, Settleman J, Hong W, Levantini E, Tenen DG. Chin TM, et al. Among authors: settleman j. Theranostics. 2020 Feb 3;10(6):2727-2743. doi: 10.7150/thno.38729. eCollection 2020. Theranostics. 2020. PMID: 32194831 Free PMC article.

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