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Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Molinaro P, Cantile M, Cuomo O, Secondo A, Pannaccione A, Ambrosino P, Pignataro G, Fiorino F, Severino B, Gatta E, Sisalli MJ, Milanese M, Scorziello A, Bonanno G, Robello M, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Molinaro P, et al. Among authors: severino b. Mol Pharmacol. 2013 Jan;83(1):142-56. doi: 10.1124/mol.112.080986. Epub 2012 Oct 11. Mol Pharmacol. 2013. PMID: 23066092
Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
Secondo A, Pignataro G, Ambrosino P, Pannaccione A, Molinaro P, Boscia F, Cantile M, Cuomo O, Esposito A, Sisalli MJ, Scorziello A, Guida N, Anzilotti S, Fiorino F, Severino B, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Secondo A, et al. Among authors: severino b. ACS Chem Neurosci. 2015 Aug 19;6(8):1361-70. doi: 10.1021/acschemneuro.5b00043. Epub 2015 May 19. ACS Chem Neurosci. 2015. PMID: 25942323
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Fiorino F, Ciano A, Magli E, Severino B, Corvino A, Perissutti E, Frecentese F, Di Vaio P, Izzo AA, Capasso R, Massarelli P, Nencini C, Rossi I, Kędzierska E, Orzelska-Gòrka J, Bielenica A, Santagada V, Caliendo G. Fiorino F, et al. Among authors: severino b. Eur J Med Chem. 2016 Mar 3;110:133-50. doi: 10.1016/j.ejmech.2016.01.021. Epub 2016 Jan 18. Eur J Med Chem. 2016. PMID: 26820556
5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives.
Bielenica A, Kędzierska E, Koliński M, Kmiecik S, Koliński A, Fiorino F, Severino B, Magli E, Corvino A, Rossi I, Massarelli P, Kozioł AE, Sawczenko A, Struga M. Bielenica A, et al. Among authors: severino b. Eur J Med Chem. 2016 Jun 30;116:173-186. doi: 10.1016/j.ejmech.2016.03.073. Epub 2016 Mar 30. Eur J Med Chem. 2016. PMID: 27061981
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.
Zotti AI, Di Gennaro E, Corvino A, Frecentese F, Magli E, Perissutti E, Cirino G, Roviezzo F, Terranova-Barberio M, Iannelli F, Caliendo G, Santagada V, Fiorino F, Budillon A, Severino B. Zotti AI, et al. Among authors: severino b. Anticancer Agents Med Chem. 2017;17(7):973-981. doi: 10.2174/1871520616666160926120904. Anticancer Agents Med Chem. 2017. PMID: 27671294
Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
Silva RN, Oliveira LCG, Parise CB, Oliveira JR, Severino B, Corvino A, di Vaio P, Temussi PA, Caliendo G, Santagada V, Juliano L, Juliano MA. Silva RN, et al. Among authors: severino b. Biochim Biophys Acta Proteins Proteom. 2017 May;1865(5):558-564. doi: 10.1016/j.bbapap.2017.02.017. Epub 2017 Feb 28. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28254587
103 results