Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2002 1
2005 2
2006 1
2008 2
2014 1
2015 1
2016 2
2017 1
2018 2
2019 1
2020 1
2021 4
2022 3
2023 5
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Results by year

Filters applied: . Clear all
Page 1
SH3BGRL Suppresses Liver Tumor Progression through Enhanced ATG5-Dependent Autophagy.
Saleh AAM, Haider F, Lv H, Liu B, Xiao J, Zhang M, Zheng Y, Yang S, Wang H. Saleh AAM, et al. J Oncol. 2023 Apr 24;2023:1105042. doi: 10.1155/2023/1105042. eCollection 2023. J Oncol. 2023. PMID: 37138798 Free PMC article.
But the function of SH3BGRL in other types of cancers is largely unknown. Here, we modulate SH3BGRL expression level in two liver cancer cells and conduct both in vitro and in vivo analyses of SH3BGRL in cell proliferation and tumorigenesis. ...The xenograft …
But the function of SH3BGRL in other types of cancers is largely unknown. Here, we modulate SH3BGRL expression level in two li …
SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.
Li H, Zhang M, Wei Y, Haider F, Lin Y, Guan W, Liu Y, Zhang S, Yuan R, Yang X, Yang S, Wang H. Li H, et al. J Exp Clin Cancer Res. 2020 May 7;39(1):81. doi: 10.1186/s13046-020-01577-z. J Exp Clin Cancer Res. 2020. PMID: 32381043 Free PMC article.
METHODS: The interaction of SH3BGRL to HER2 were characterized with various truncated SH3BGRL mutants by immunoprecipitation and molecule docking simulation. ...Thus, targeting SH3BGRL or the downstream signaling could relieve the innate resistance to some HE …
METHODS: The interaction of SH3BGRL to HER2 were characterized with various truncated SH3BGRL mutants by immunoprecipitation a …
Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.
Zhang S, Liu X, Abdulmomen Ali Mohammed S, Li H, Cai W, Guan W, Liu D, Wei Y, Rong D, Fang Y, Haider F, Lv H, Jin Z, Chen X, Mo Z, Li L, Yang S, Wang H. Zhang S, et al. Autophagy. 2022 Aug;18(8):1822-1840. doi: 10.1080/15548627.2021.2002108. Epub 2021 Dec 6. Autophagy. 2022. PMID: 34870550 Free PMC article.
Functionally, SH3BGRL upregulation enhances the chemoresistance of breast cancer cells to the first-line doxorubicin treatment through macroautophagic/autophagic protection. Mechanistically, SH3BGRL can unexpectedly bind to ribosomal subunits to enhance PIK3C3 trans …
Functionally, SH3BGRL upregulation enhances the chemoresistance of breast cancer cells to the first-line doxorubicin treatment throug …
Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation.
Zhang S, Guo X, Liu X, Zhong Z, Yang S, Wang H. Zhang S, et al. Oncogene. 2021 Sep;40(38):5677-5690. doi: 10.1038/s41388-021-01970-8. Epub 2021 Jul 30. Oncogene. 2021. PMID: 34331014
Mechanistically, SH3BGRL downregulates the acting-binding protein profilin 1 (PFN1) by accelerating the translation of the PFN1 E3 ligase, STUB1 via SH3BGRL interaction with ribosomal proteins, or/and enhancing the interaction of PFN1 with STUB1 to accelerate PFN1 d …
Mechanistically, SH3BGRL downregulates the acting-binding protein profilin 1 (PFN1) by accelerating the translation of the PFN1 E3 li …
SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.
Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li J, Yang S, Tong X, Wang H. Xu L, et al. Leuk Lymphoma. 2018 Apr;59(4):918-930. doi: 10.1080/10428194.2017.1344843. Epub 2017 Jul 6. Leuk Lymphoma. 2018. PMID: 28679293
Here, we followed up and validated the relevance of SH3BGRL expression to AML progression in 116 cases. Results showed that SH3BGRL is down-regulated in 62.37% AML cases with poor prognosis. ...Xenograft assays further confirmed the suppressive role of SH3BGRL …
Here, we followed up and validated the relevance of SH3BGRL expression to AML progression in 116 cases. Results showed that SH3BGR …
EZH2-mediated epigenetic suppression of SH3BGRL potently inhibits lung cancer progression.
Liu Z, Xu W, Tan X, Li C. Liu Z, et al. Biochem Biophys Res Commun. 2021 Apr 9;548:53-59. doi: 10.1016/j.bbrc.2021.02.056. Epub 2021 Feb 22. Biochem Biophys Res Commun. 2021. PMID: 33631674
Moreover, SH3BGRL was also weakly expressed in lung CSCs compared with its corresponding lung cancer cells. We first characterize that EZH2 directly binds to SH3BGRL promoter and transcriptional represses SH3BGRL expression in epigenetic level. ...
Moreover, SH3BGRL was also weakly expressed in lung CSCs compared with its corresponding lung cancer cells. We first characterize tha …
Decitabine Enhances Acute Myeloid Leukemia Cell Apoptosis through SH3BGRL Upregulation.
Chen X, Liu F, Rong D, Xu L, Tong X, Wang H. Chen X, et al. Anticancer Agents Med Chem. 2022;22(12):2274-2281. doi: 10.2174/1871520622666211228110630. Anticancer Agents Med Chem. 2022. PMID: 34963436
Our previous results revealed that human SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL) plays a tumor suppressive role in AML but whether there is a connection between DAC and SH3BGRL expression remains elusive. ...In U937 cell lines, treatment …
Our previous results revealed that human SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL) plays a tumor suppressi …
Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish.
Jin Z, Wang D, Lv H, Wu B, Li Z, Guo X, Wang H, Yang S. Jin Z, et al. FEBS Lett. 2023 Nov;597(21):2643-2655. doi: 10.1002/1873-3468.14733. Epub 2023 Sep 20. FEBS Lett. 2023. PMID: 37698355
Here, we found that the small adaptor protein SH3-domain-binding glutamate-rich protein like (Sh3bgrl) plays an important role in female reproduction in zebrafish. Two sh3bgrl mutant alleles that result in sh3bgrl depletion contribute to female spawning inabi …
Here, we found that the small adaptor protein SH3-domain-binding glutamate-rich protein like (Sh3bgrl) plays an important role in fem …
Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.
Wang H, Liu B, Al-Aidaroos AQ, Shi H, Li L, Guo K, Li J, Tan BC, Loo JM, Tang JP, Thura M, Zeng Q. Wang H, et al. Oncogene. 2016 Jun 23;35(25):3303-13. doi: 10.1038/onc.2015.391. Epub 2015 Oct 12. Oncogene. 2016. PMID: 26455318 Free PMC article.
Here, we first report the discovery of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL), a novel c-Src activator in mice. Ectopic expression of murine SH3BGRL (mSH3BGRL) strongly promoted both tumor cell invasion and lung metastasis. ... …
Here, we first report the discovery of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL), a novel c-Src a …
26 results