Shackleford DM - Search Results

1

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL. Charman SA, et al. Among authors: shackleford dm. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7. Proc Natl Acad Sci U S A. 2011. PMID: 21300861 Free PMC article.

2

Self-micellization of gemfibrozil 1-O-beta acyl glucuronide in aqueous solution.

Shackleford DM, Prankerd RJ, Scanlon MJ, Charman WN. Shackleford DM, et al. Pharm Res. 2003 Mar;20(3):465-70. doi: 10.1023/a:1022672608657. Pharm Res. 2003. PMID: 12669970

3

Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?

Shackleford DM, Porter CJ, Charman WN. Shackleford DM, et al. Biopharm Drug Dispos. 2003 May;24(4):153-7. doi: 10.1002/bdd.351. Biopharm Drug Dispos. 2003. PMID: 12698498

4

Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs.

Shackleford DM, Faassen WA, Houwing N, Lass H, Edwards GA, Porter CJ, Charman WN. Shackleford DM, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):925-33. doi: 10.1124/jpet.103.052522. Epub 2003 Jun 13. J Pharmacol Exp Ther. 2003. PMID: 12807999

5

Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.

Khoo SM, Shackleford DM, Porter CJ, Edwards GA, Charman WN. Khoo SM, et al. Among authors: shackleford dm. Pharm Res. 2003 Sep;20(9):1460-5. doi: 10.1023/a:1025718513246. Pharm Res. 2003. PMID: 14567642

6

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.

Trevaskis NL, Shackleford DM, Charman WN, Edwards GA, Gardin A, Appel-Dingemanse S, Kretz O, Galli B, Porter CJ. Trevaskis NL, et al. Among authors: shackleford dm. Pharm Res. 2009 Jun;26(6):1486-95. doi: 10.1007/s11095-009-9860-z. Epub 2009 Mar 12. Pharm Res. 2009. PMID: 19280324

7

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

Gujjar R, Marwaha A, El Mazouni F, White J, White KL, Creason S, Shackleford DM, Baldwin J, Charman WN, Buckner FS, Charman S, Rathod PK, Phillips MA. Gujjar R, et al. Among authors: shackleford dm. J Med Chem. 2009 Apr 9;52(7):1864-72. doi: 10.1021/jm801343r. J Med Chem. 2009. PMID: 19296651 Free PMC article.

8

Discovery of CYT997: a structurally novel orally active microtubule targeting agent.

Burns CJ, Harte MF, Bu X, Fantino E, Joffe M, Sikanyika H, Su S, Tranberg CE, Wilson N, Charman SA, Shackleford DM, Wilks AF. Burns CJ, et al. Among authors: shackleford dm. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4639-42. doi: 10.1016/j.bmcl.2009.06.079. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19616947

9

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.

Bhamidipati RK, Morizzi J, Chiu FC, Shackleford DM, Charman SA. Bhamidipati RK, et al. Among authors: shackleford dm. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):2989-95. doi: 10.1016/j.jchromb.2009.07.015. Epub 2009 Jul 17. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19646936

10

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE(7)-beta-CD on the disposition of chlorpromazine in the rat.

McIntosh MP, Leong N, Katneni K, Morizzi J, Shackleford DM, Prankerd RJ. McIntosh MP, et al. Among authors: shackleford dm. J Pharm Sci. 2010 Jul;99(7):2999-3008. doi: 10.1002/jps.22064. J Pharm Sci. 2010. PMID: 20091817

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