SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.
Li M, Hong W, Hao C, Li L, Wu D, Shen A, Lu J, Zheng Y, Li P, Xu Y.
Li M, et al. Among authors: shen a.
FASEB J. 2018 Jan;32(1):500-511. doi: 10.1096/fj.201700612R. Epub 2017 Sep 26.
FASEB J. 2018.
PMID: 28970250
Hepatic stellate cells (HSCs) are a major source of fibrogenesis in the liver, contributing to cirrhosis. ...In summary, our data suggest that SIRT1 plays an essential role guiding the transition of HSC phenotypes.-Li, M., Hong, W., Hao, C., Li, L., Wu, D., Shen, …
Hepatic stellate cells (HSCs) are a major source of fibrogenesis in the liver, contributing to cirrhosis. ...In summary, our data sug …