Shen B - Search Results

1

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates.

Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. Guo X, et al. Among authors: shen b. Biochemistry. 2018 Feb 13;57(6):1003-1011. doi: 10.1021/acs.biochem.7b01219. Epub 2018 Jan 30. Biochemistry. 2018. PMID: 29341603

2

BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.

Du L, Chen M, Zhang Y, Shen B. Du L, et al. Among authors: shen b. Biochemistry. 2003 Aug 19;42(32):9731-40. doi: 10.1021/bi034817r. Biochemistry. 2003. PMID: 12911315

3

Iterative type I polyketide synthases for enediyne core biosynthesis.

Horsman GP, Van Lanen SG, Shen B. Horsman GP, et al. Among authors: shen b. Methods Enzymol. 2009;459:97-112. doi: 10.1016/S0076-6879(09)04605-9. Methods Enzymol. 2009. PMID: 19362637 Free PMC article.

4

Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.

Lin S, Horsman GP, Chen Y, Li W, Shen B. Lin S, et al. Among authors: shen b. J Am Chem Soc. 2009 Nov 18;131(45):16410-7. doi: 10.1021/ja901242s. J Am Chem Soc. 2009. PMID: 19856960 Free PMC article.

5

Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster.

Lin S, Horsman GP, Shen B. Lin S, et al. Among authors: shen b. Org Lett. 2010 Sep 3;12(17):3816-9. doi: 10.1021/ol101473t. Org Lett. 2010. PMID: 20704329 Free PMC article.

6

Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.

Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B. Ling J, et al. Among authors: shen b. J Am Chem Soc. 2010 Sep 15;132(36):12534-6. doi: 10.1021/ja1050814. J Am Chem Soc. 2010. PMID: 20718468 Free PMC article.

7

The missing C-17 O-methyltransferase in geldanamycin biosynthesis.

Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B. Yin M, et al. Among authors: shen b. Org Lett. 2011 Jul 15;13(14):3726-9. doi: 10.1021/ol201383w. Epub 2011 Jun 17. Org Lett. 2011. PMID: 21682254

8

Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.

Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B. Lin S, et al. Among authors: shen b. Org Lett. 2012 May 4;14(9):2300-3. doi: 10.1021/ol300720s. Epub 2012 Apr 20. Org Lett. 2012. PMID: 22519717 Free PMC article.

9

4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis.

Lohman JR, Shen B. Lohman JR, et al. Among authors: shen b. Methods Enzymol. 2012;516:299-319. doi: 10.1016/B978-0-12-394291-3.00007-1. Methods Enzymol. 2012. PMID: 23034235

10

Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold.

Lohman JR, Bingman CA, Phillips GN Jr, Shen B. Lohman JR, et al. Among authors: shen b. Biochemistry. 2013 Feb 5;52(5):902-11. doi: 10.1021/bi301652y. Epub 2013 Jan 24. Biochemistry. 2013. PMID: 23320975 Free PMC article.

In vitro biochemical investigation confirmed that LnmK is a bifunctional acyltransferase/decarboxylase (AT/DC) that catalyzes first self-acylation using methylmalonyl-CoA as a substrate and subsequently transacylation of the methylmalonyl group to the phosphopantetheinyl group of …

In vitro biochemical investigation confirmed that LnmK is a bifunctional acyltransferase/decarboxylase (AT/DC) that catalyzes first self-acy …

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