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Crystal structure of human IRAK1.
Wang L, Qiao Q, Ferrao R, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H. Wang L, et al. Among authors: shen c. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13507-13512. doi: 10.1073/pnas.1714386114. Epub 2017 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 29208712 Free PMC article.
Mechanism of ubiquitin transfer promoted by TRAF6.
Fu TM, Shen C, Li Q, Zhang P, Wu H. Fu TM, et al. Among authors: shen c. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1783-1788. doi: 10.1073/pnas.1721788115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432170 Free PMC article.
Molecular mechanism for NLRP6 inflammasome assembly and activation.
Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Shen C, et al. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23. Proc Natl Acad Sci U S A. 2019. PMID: 30674671 Free PMC article.
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Lee YR, et al. Among authors: shen c. Science. 2019 May 17;364(6441):eaau0159. doi: 10.1126/science.aau0159. Science. 2019. PMID: 31097636 Free PMC article.
Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1.
Cui Y, Keles S, Charbonnier LM, Julé AM, Henderson L, Celik SC, Reisli I, Shen C, Xie WJ, Schmitz-Abe K, Wu H, Chatila TA. Cui Y, et al. Among authors: shen c. J Allergy Clin Immunol. 2020 Jan;145(1):391-401.e8. doi: 10.1016/j.jaci.2019.10.004. Epub 2019 Oct 16. J Allergy Clin Immunol. 2020. PMID: 31629014 Free PMC article. Clinical Trial.
Multiple domain interfaces mediate SARM1 autoinhibition.
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Shen C, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2023151118. doi: 10.1073/pnas.2023151118. Proc Natl Acad Sci U S A. 2021. PMID: 33468661 Free PMC article.
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