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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium; Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Wiseman FK, et al. Among authors: sheppard o. Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Brain. 2018. PMID: 29945247 Free PMC article.
Mouse models of aneuploidy.
Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM. Sheppard O, et al. ScientificWorldJournal. 2012;2012:214078. doi: 10.1100/2012/214078. Epub 2012 Jan 3. ScientificWorldJournal. 2012. PMID: 22262951 Free PMC article. Review.
Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.
Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E, Yang F, Maguire S, Fu B, Rajan D, Sheppard O, Scott C, Hauser H, Stephens PJ, Stebbings LA, Ng BL, Fitzgerald T, Quail MA, Banerjee R, Rothkamm K, Tybulewicz VL, Fisher EM, Carter NP. Gribble SM, et al. Among authors: sheppard o. PLoS One. 2013 Apr 15;8(4):e60482. doi: 10.1371/journal.pone.0060482. Print 2013. PLoS One. 2013. PMID: 23596509 Free PMC article.
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, Simpson TI, Tybulewicz VL, Wyllie DJ, Fisher EM, Lowell S, Chandran S, Hardingham GE. Qiu J, et al. Among authors: sheppard o. Elife. 2016 Oct 1;5:e20337. doi: 10.7554/eLife.20337. Elife. 2016. PMID: 27692071 Free PMC article.
32 results