Shertzer HG - Search Results

1

Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.

Uno S, Wang B, Shertzer HG, Nebert DW, Dalton TP. Uno S, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2003 Dec 12;312(2):494-9. doi: 10.1016/j.bbrc.2003.10.145. Biochem Biophys Res Commun. 2003. PMID: 14637164

2

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW. Jiang Z, et al. Among authors: shertzer hg. Hum Mutat. 2005 Feb;25(2):196-206. doi: 10.1002/humu.20134. Hum Mutat. 2005. PMID: 15643613

3

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

Derkenne S, Curran CP, Shertzer HG, Dalton TP, Dragin N, Nebert DW. Derkenne S, et al. Among authors: shertzer hg. Pharmacogenet Genomics. 2005 Jul;15(7):503-11. doi: 10.1097/01.fpc.0000167326.00411.50. Pharmacogenet Genomics. 2005. PMID: 15970798

4

Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG. Genter MB, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1375-81. doi: 10.1016/j.bbrc.2006.02.121. Epub 2006 Feb 28. Biochem Biophys Res Commun. 2006. PMID: 16516144

5

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.

Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW. Dragin N, et al. Among authors: shertzer hg. J Biol Chem. 2006 Jul 7;281(27):18591-600. doi: 10.1074/jbc.M601159200. Epub 2006 Apr 24. J Biol Chem. 2006. PMID: 16636061 Free article.

6

Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Dong H, et al. Among authors: shertzer hg. Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Epub 2008 Dec 1. Mol Pharmacol. 2009. PMID: 19047483 Free PMC article.

7

Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW. Dong H, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2013 Jun 14;435(4):727-32. doi: 10.1016/j.bbrc.2013.05.051. Epub 2013 May 18. Biochem Biophys Res Commun. 2013. PMID: 23692925 Free PMC article.

8

Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.

Dalton TP, Dieter MZ, Matlib RS, Childs NL, Shertzer HG, Genter MB, Nebert DW. Dalton TP, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2000 Jan 7;267(1):184-9. doi: 10.1006/bbrc.1999.1913. Biochem Biophys Res Commun. 2000. PMID: 10623596

9

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW. Dalton TP, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2000 Dec 20;279(2):324-9. doi: 10.1006/bbrc.2000.3930. Biochem Biophys Res Commun. 2000. PMID: 11118286

10

Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.

Uno S, Dalton TP, Shertzer HG, Genter MB, Warshawsky D, Talaska G, Nebert DW. Uno S, et al. Among authors: shertzer hg. Biochem Biophys Res Commun. 2001 Dec 21;289(5):1049-56. doi: 10.1006/bbrc.2001.6110. Biochem Biophys Res Commun. 2001. PMID: 11741297

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