Shimano H - Search Results

1

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB. Park HJ, et al. Among authors: shimano h. J Clin Invest. 2008 Jan;118(1):259-71. doi: 10.1172/JCI32011. J Clin Invest. 2008. PMID: 18060044 Free PMC article.

2

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Shimano H, et al. J Clin Invest. 1996 Oct 1;98(7):1575-84. doi: 10.1172/JCI118951. J Clin Invest. 1996. PMID: 8833906 Free PMC article.

3

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Shimomura I, et al. Among authors: shimano h. J Clin Invest. 1997 Mar 1;99(5):838-45. doi: 10.1172/JCI119247. J Clin Invest. 1997. PMID: 9062340 Free PMC article.

4

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Shimano H, et al. J Clin Invest. 1997 Mar 1;99(5):846-54. doi: 10.1172/JCI119248. J Clin Invest. 1997. PMID: 9062341 Free PMC article.

5

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Shimano H, et al. J Clin Invest. 1997 Oct 15;100(8):2115-24. doi: 10.1172/JCI119746. J Clin Invest. 1997. PMID: 9329978 Free PMC article.

6

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Horton JD, et al. Among authors: shimano h. J Clin Invest. 1998 Jun 1;101(11):2331-9. doi: 10.1172/JCI2961. J Clin Invest. 1998. PMID: 9616204 Free PMC article.

7

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL. Horton JD, et al. Among authors: shimano h. J Clin Invest. 1999 Apr;103(7):1067-76. doi: 10.1172/JCI6246. J Clin Invest. 1999. PMID: 10194480 Free PMC article.

8

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.

Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M, Noda T. Matsumoto M, et al. Among authors: shimano h. J Clin Invest. 2003 Sep;112(6):935-44. doi: 10.1172/JCI18816. J Clin Invest. 2003. PMID: 12975478 Free PMC article.

9

SREBP inhibits VEGF expression in human smooth muscle cells.

Motoyama K, Fukumoto S, Koyama H, Emoto M, Shimano H, Maemura K, Nishizawa Y. Motoyama K, et al. Among authors: shimano h. Biochem Biophys Res Commun. 2006 Mar 31;342(1):354-60. doi: 10.1016/j.bbrc.2006.01.139. Epub 2006 Feb 3. Biochem Biophys Res Commun. 2006. PMID: 16480961

10

Novel role for the CRTC2 in lipid homeostasis.

Matsuzaka T, Shimano H. Matsuzaka T, et al. Among authors: shimano h. J Diabetes Investig. 2016 Sep;7(5):677-9. doi: 10.1111/jdi.12497. Epub 2016 Mar 24. J Diabetes Investig. 2016. PMID: 27181382 Free PMC article.

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