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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity.
Shinkawa T, Nakamura K, Yamane N, Shoji-Hosaka E, Kanda Y, Sakurada M, Uchida K, Anazawa H, Satoh M, Yamasaki M, Hanai N, Shitara K. Shinkawa T, et al. Among authors: shitara k. J Biol Chem. 2003 Jan 31;278(5):3466-73. doi: 10.1074/jbc.M210665200. Epub 2002 Nov 8. J Biol Chem. 2003. PMID: 12427744 Free article.
Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity.
Yamane-Ohnuki N, Kinoshita S, Inoue-Urakubo M, Kusunoki M, Iida S, Nakano R, Wakitani M, Niwa R, Sakurada M, Uchida K, Shitara K, Satoh M. Yamane-Ohnuki N, et al. Among authors: shitara k. Biotechnol Bioeng. 2004 Sep 5;87(5):614-22. doi: 10.1002/bit.20151. Biotechnol Bioeng. 2004. PMID: 15352059
444 results