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Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.
Petersen MC, Smith GI, Palacios HH, Farabi SS, Yoshino M, Yoshino J, Cho K, Davila-Roman VG, Shankaran M, Barve RA, Yu J, Stern JH, Patterson BW, Hellerstein MK, Shulman GI, Patti GJ, Klein S. Petersen MC, et al. Among authors: shulman gi. Cell Metab. 2024 Apr 2;36(4):745-761.e5. doi: 10.1016/j.cmet.2024.03.002. Cell Metab. 2024. PMID: 38569471 Free article.
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
Sakuma I, Gaspar RC, Luukkonen PK, Kahn M, Zhang D, Zhang X, Murray S, Golla JP, Vatner DF, Samuel VT, Petersen KF, Shulman GI. Sakuma I, et al. Among authors: shulman gi. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2312666120. doi: 10.1073/pnas.2312666120. Epub 2023 Dec 21. Proc Natl Acad Sci U S A. 2023. PMID: 38127985
The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.
Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtimäki TE, Seppänen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-Järvinen H. Luukkonen PK, et al. Among authors: shulman gi. Cell Metab. 2023 Nov 7;35(11):1887-1896.e5. doi: 10.1016/j.cmet.2023.10.008. Epub 2023 Oct 30. Cell Metab. 2023. PMID: 37909034 Free article.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.
Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D. Mooring M, et al. Among authors: shulman gi. Sci Transl Med. 2023 Sep 27;15(715):eade3157. doi: 10.1126/scitranslmed.ade3157. Epub 2023 Sep 27. Sci Transl Med. 2023. PMID: 37756381 Free PMC article.
O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding.
Nakamoto A, Ohashi N, Sugawara L, Morino K, Ida S, Perry RJ, Sakuma I, Yanagimachi T, Fujita Y, Ugi S, Kume S, Shulman GI, Maegawa H. Nakamoto A, et al. Among authors: shulman gi. Am J Physiol Endocrinol Metab. 2023 Jul 1;325(1):E46-E61. doi: 10.1152/ajpendo.00263.2022. Epub 2023 May 24. Am J Physiol Endocrinol Metab. 2023. PMID: 37224467
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