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Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models.
Homer-Bouthiette C, Zhao Y, Shunkwiler LB, Van Peel B, Garrett-Mayer E, Baird RC, Rissman AI, Guest ST, Ethier SP, John MC, Powers PA, Haag JD, Gould MN, Smits BMG. Homer-Bouthiette C, et al. Among authors: shunkwiler lb. BMC Cancer. 2018 Dec 10;18(1):1233. doi: 10.1186/s12885-018-5109-8. BMC Cancer. 2018. PMID: 30526553 Free PMC article.
Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.
Ding L, Shunkwiler LB, Harper NW, Zhao Y, Hinohara K, Huh SJ, Ekram MB, Guz J, Kern MJ, Awgulewitsch A, Shull JD, Smits BMG, Polyak K. Ding L, et al. Among authors: shunkwiler lb. PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar. PLoS Genet. 2019. PMID: 30893315 Free PMC article.