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Page 1
The role of Siah2 in tumorigenesis and cancer therapy.
Li K, Li J, Ye M, Jin X. Li K, et al. Gene. 2022 Jan 30;809:146028. doi: 10.1016/j.gene.2021.146028. Epub 2021 Oct 20. Gene. 2022. PMID: 34687788 Review.
Moreover, Siah2 is subject to complex regulation, especially the phosphorylation of Siah2 by a variety of protein kinases to regulate its stability and activity. In this review, we describe the structure and regulation of Siah2 in human cancer. Moreover, we h …
Moreover, Siah2 is subject to complex regulation, especially the phosphorylation of Siah2 by a variety of protein kinases to r …
Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy.
Xu D, Li C. Xu D, et al. Front Cell Dev Biol. 2021 Mar 25;9:646687. doi: 10.3389/fcell.2021.646687. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33842469 Free PMC article. Review.
This SIAH2-HIF-1 signaling axis is important for maintaining the level of HIF-1alpha under both normoxic and hypoxic conditions. ...In this review, we will discuss the regulation of the SIAH2-HIF-1 axis via phosphorylation of SIAH2 by these kinases and the po …
This SIAH2-HIF-1 signaling axis is important for maintaining the level of HIF-1alpha under both normoxic and hypoxic conditions. ...I …
Siah2 control of T-regulatory cells limits anti-tumor immunity.
Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA. Scortegagna M, et al. Nat Commun. 2020 Jan 7;11(1):99. doi: 10.1038/s41467-019-13826-7. Nat Commun. 2020. PMID: 31911617 Free PMC article.
Growth of anti-PD-1 therapy resistant melanoma is effectively inhibited in Siah2(-/-) mice subjected to PD-1 blockade, indicating synergy between PD-1 blockade and Siah2 loss. ...Overall, Siah2 regulation of Treg recruitment and cell cycle progression effecti …
Growth of anti-PD-1 therapy resistant melanoma is effectively inhibited in Siah2(-/-) mice subjected to PD-1 blockade, indicating syn …
SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway.
Hu Y, He Y, Liu W, Yu S, Wei Y, Bai S, Su Y, Xiao B. Hu Y, et al. Tissue Cell. 2022 Oct;78:101878. doi: 10.1016/j.tice.2022.101878. Epub 2022 Jul 29. Tissue Cell. 2022. PMID: 35926257
However, the biological role of SIAH2 in colorectal cancer tumorigenesis remains controversial. In this work, we found that SIAH2 is an oncogene in colorectal cancer. ...Mechanistically, SIAH2 promoted the PI3K/AKT signaling pathway both in vivo and in vitro. …
However, the biological role of SIAH2 in colorectal cancer tumorigenesis remains controversial. In this work, we found that SIAH2 …
Siah2-GRP78 interaction regulates ROS and provides a proliferative advantage to Helicobacter pylori-infected gastric epithelial cancer cells.
Dixit P, Suratkal SS, Kokate SB, Chakraborty D, Poirah I, Samal S, Rout N, Singh SP, Sarkar A, Bhattacharyya A. Dixit P, et al. Cell Mol Life Sci. 2022 Jul 11;79(8):414. doi: 10.1007/s00018-022-04437-5. Cell Mol Life Sci. 2022. PMID: 35816252 Free PMC article.
We identify that H. pylori-mediated Siah2 phosphorylation at the 6th serine residue (P-S(6)-Siah2) enhances proteasomal degradation of the 78-kDa glucose-regulated protein (GRP78) possessing antioxidant functions. S(6) phosphorylation stabilizes Siah2 and P-S …
We identify that H. pylori-mediated Siah2 phosphorylation at the 6th serine residue (P-S(6)-Siah2) enhances proteasomal degrad …
SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.
Jeong SY, Hariharasudhan G, Kim MJ, Lim JY, Jung SM, Choi EJ, Chang IY, Kee Y, You HJ, Lee JH. Jeong SY, et al. Nucleic Acids Res. 2022 Oct 14;50(18):10469-10486. doi: 10.1093/nar/gkac808. Nucleic Acids Res. 2022. PMID: 36155803 Free PMC article.
Here, we provide evidence that CtIP recruitment and functioning are controlled by the SIAH2 E3 ubiquitin ligase. We found that SIAH2 interacts and ubiquitinates CtIP at its N-terminal lysine residues. ...Depleting SIAH2 consistently phenocopied these results. …
Here, we provide evidence that CtIP recruitment and functioning are controlled by the SIAH2 E3 ubiquitin ligase. We found that SIA …
SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with EBF1 and ZFP521 to Promote Adipogenesis.
Dang TN, Taylor JL, Kilroy G, Yu Y, Burk DH, Floyd ZE. Dang TN, et al. Obesity (Silver Spring). 2021 Jan;29(1):98-107. doi: 10.1002/oby.23013. Epub 2020 Nov 6. Obesity (Silver Spring). 2021. PMID: 33155406 Free PMC article.
METHODS: SIAH2 expression in precursor cells was assessed in primary cells and tissues from wild-type and SIAH2 null mice fed a control or high-fat diet. Primary cells, 3T3-L1 preadipocytes, and HEK293T cells were used to analyze Siah2, Ebf1, and Zfp521 expre …
METHODS: SIAH2 expression in precursor cells was assessed in primary cells and tissues from wild-type and SIAH2 null mice fed …
The Siah2-HIF-FoxA2 axis in prostate cancer - new markers and therapeutic opportunities.
Qi J, Pellecchia M, Ronai ZA. Qi J, et al. Oncotarget. 2010 Sep;1(5):379-85. doi: 10.18632/oncotarget.171. Oncotarget. 2010. PMID: 21037926 Free PMC article. Review.
Recent studies indicate the importance of the ubiquitin ligase Siah2 in control of more aggressive prostate tumors - namely, neuroendocrine (NE) prostate tumors and prostate adenocarcinoma (PCa) harboring neuroendocrine lesions. Siah2-dependent expression and activi …
Recent studies indicate the importance of the ubiquitin ligase Siah2 in control of more aggressive prostate tumors - namely, neuroend …
Helicobacter pylori-induced gastric cancer is orchestrated by MRCKbeta-mediated Siah2 phosphorylation.
Dixit P, Kokate SB, Poirah I, Chakraborty D, Smoot DT, Ashktorab H, Rout N, Singh SP, Bhattacharyya A. Dixit P, et al. J Biomed Sci. 2021 Feb 3;28(1):12. doi: 10.1186/s12929-021-00710-0. J Biomed Sci. 2021. PMID: 33536006 Free PMC article.
MRCKbeta-dependent Siah2 phosphorylation stabilized Siah2 which promoted anchorage-independent survival and proliferative potential of GECs. Phospho-null mutants of Siah2 (S6A and T279A) showed abated tumorigenicity....
MRCKbeta-dependent Siah2 phosphorylation stabilized Siah2 which promoted anchorage-independent survival and proliferative pote …
The ubiquitin ligase Siah2 and the hypoxia response.
Nakayama K, Qi J, Ronai Z. Nakayama K, et al. Mol Cancer Res. 2009 Apr;7(4):443-51. doi: 10.1158/1541-7786.MCR-08-0458. Mol Cancer Res. 2009. PMID: 19372575 Free PMC article. Review.
Growing evidence also indicates an important function for Siah2 in tumor development and progression based on pancreatic cancer, mammary tumor, and melanoma mouse models. This review summarizes our current understanding of Siah2 regulation and function with emphasis …
Growing evidence also indicates an important function for Siah2 in tumor development and progression based on pancreatic cancer, mamm …
237 results