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1999 2
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2001 2
2002 3
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2005 3
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2007 5
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2009 5
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Mechanistic Insights into the Pharmacological Significance of Silymarin.
Wadhwa K, Pahwa R, Kumar M, Kumar S, Sharma PC, Singh G, Verma R, Mittal V, Singh I, Kaushik D, Jeandet P. Wadhwa K, et al. Molecules. 2022 Aug 21;27(16):5327. doi: 10.3390/molecules27165327. Molecules. 2022. PMID: 36014565 Free PMC article. Review.
Silymarin is a plant-derived mixture of polyphenolic flavonoids originating from the fruits and akenes of Silybum marianum and contains three flavonolignans, silibinins (silybins), silychristin and silydianin, along with taxifolin. Silybins are the major constituents in si …
Silymarin is a plant-derived mixture of polyphenolic flavonoids originating from the fruits and akenes of Silybum marianum and contains thre …
Milk thistle in liver diseases: past, present, future.
Abenavoli L, Capasso R, Milic N, Capasso F. Abenavoli L, et al. Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002/ptr.3207. Phytother Res. 2010. PMID: 20564545 Review.
The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and m …
The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydi …
Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review.
Soleimani V, Delghandi PS, Moallem SA, Karimi G. Soleimani V, et al. Phytother Res. 2019 Jun;33(6):1627-1638. doi: 10.1002/ptr.6361. Epub 2019 May 8. Phytother Res. 2019. PMID: 31069872 Review.
Silymarin was mutagen in Salmonella typhimurium strains in the presence of metabolic enzymes. Silybin, silydianin, and silychristin were not cytotoxic and genotoxic at concentration of 100 muM. ...
Silymarin was mutagen in Salmonella typhimurium strains in the presence of metabolic enzymes. Silybin, silydianin, and silychristin w …
An updated systematic review with meta-analysis for the clinical evidence of silymarin.
Saller R, Brignoli R, Melzer J, Meier R. Saller R, et al. Forsch Komplementmed. 2008 Feb;15(1):9-20. doi: 10.1159/000113648. Forsch Komplementmed. 2008. PMID: 18334810 Free article. Review.
METHODS: For this systematic review electronic databases identified 65 papers for the search terms silymarin, silibinin, silicristin or milk thistle and clinical trial. Only 19 complied with the criteria'double-' or 'single-blind'. ...
METHODS: For this systematic review electronic databases identified 65 papers for the search terms silymarin, silibinin, silicristin …
An updated systematic review of the pharmacology of silymarin.
Saller R, Melzer J, Reichling J, Brignoli R, Meier R. Saller R, et al. Forsch Komplementmed. 2007 Apr;14(2):70-80. doi: 10.1159/000100581. Epub 2007 Apr 23. Forsch Komplementmed. 2007. PMID: 17464157 Review.
METHODS: Electronic databases identified silymarin, silibinin, silicristin or milk thistle as descriptors in >700 papers (34% published in last 5 years; 92% dealt with animal pharmacological). ...
METHODS: Electronic databases identified silymarin, silibinin, silicristin or milk thistle as descriptors in >700 papers (34% publ …
Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.
Koltai T, Fliegel L. Koltai T, et al. J Evid Based Integr Med. 2022 Jan-Dec;27:2515690X211068826. doi: 10.1177/2515690X211068826. J Evid Based Integr Med. 2022. PMID: 35018864 Free PMC article. Review.
The 3 more important isomers are silybin (or silibinin), silydianin, and silychristin. Silybin is functionally the most active of these compounds. ...
The 3 more important isomers are silybin (or silibinin), silydianin, and silychristin. Silybin is functionally the most active of the …
Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Cirsium Species Extracts.
Zhao ZW, Chang HC, Ching H, Lien JC, Huang HC, Wu CR. Zhao ZW, et al. Molecules. 2021 Jun 28;26(13):3935. doi: 10.3390/molecules26133935. Molecules. 2021. PMID: 34203213 Free PMC article.
Among the major constituents, silicristin had the best radical-scavenging activities against DPPH (71.68 0.66 mg catechin/g) and ABTS (3.01 0.01 mmol Trolox/g). However, diosmetin had the best reducing power and radical-scavenging activity against the hypochlorite anion (4 …
Among the major constituents, silicristin had the best radical-scavenging activities against DPPH (71.68 0.66 mg catechin/g) and ABTS …
Selectively Halogenated Flavonolignans-Preparation and Antibacterial Activity.
Hurtová M, Káňová K, Dobiasová S, Holasová K, Čáková D, Hoang L, Biedermann D, Kuzma M, Cvačka J, Křen V, Viktorová J, Valentová K. Hurtová M, et al. Int J Mol Sci. 2022 Dec 1;23(23):15121. doi: 10.3390/ijms232315121. Int J Mol Sci. 2022. PMID: 36499444 Free PMC article.
A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and 2,3-dehydrosilychristin A) was prepared. The effect of halogenation on the biological activity of flavonolignans was investigated. ...
A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and …
Silybin and its congeners: from traditional medicine to molecular effects.
Křen V, Valentová K. Křen V, et al. Nat Prod Rep. 2022 Jun 22;39(6):1264-1281. doi: 10.1039/d2np00013j. Nat Prod Rep. 2022. PMID: 35510639 Review.
A major component of silymarin is the flavonolignan silybin and its relatives isosilybin, silychristin, silydianin, 2,3-dehydrosilybin, and some others. Except for silydianin, they occur in nature as two stereomers. ...
A major component of silymarin is the flavonolignan silybin and its relatives isosilybin, silychristin, silydianin, 2,3-dehydrosilybi …
Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications.
Vargas-Mendoza N, Morales-González Á, Morales-Martínez M, Soriano-Ursúa MA, Delgado-Olivares L, Sandoval-Gallegos EM, Madrigal-Bujaidar E, Álvarez-González I, Madrigal-Santillán E, Morales-Gonzalez JA. Vargas-Mendoza N, et al. Biomedicines. 2020 May 14;8(5):122. doi: 10.3390/biomedicines8050122. Biomedicines. 2020. PMID: 32423098 Free PMC article. Review.
Several properties had been attributed to the major SM flavolignans components, identified as silybin, isosilybin, silychristin, isosilychristin, and silydianin. Previous research reported antioxidant and protective activities, which are probably related to the activation …
Several properties had been attributed to the major SM flavolignans components, identified as silybin, isosilybin, silychristin, isos …
168 results