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Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.
Senkpeil L, Bhardwaj J, Little MR, Holla P, Upadhye A, Fusco EM, Swanson Ii PA, Wiegand RE, Macklin MD, Bi K, Flynn BJ, Yamamoto A, Gaskin EL, Sather DN, Oblak AL, Simpson E, Gao H, Haining WN, Yates KB, Liu X, Murshedkar T, Richie TL, Sim BKL, Otieno K, Kariuki S, Xuei X, Liu Y, Polidoro RB, Hoffman SL, Oneko M, Steinhardt LC, Schmidt NW, Seder RA, Tran TM. Senkpeil L, et al. Among authors: sim bkl. JCI Insight. 2024 Apr 30:e167408. doi: 10.1172/jci.insight.167408. Online ahead of print. JCI Insight. 2024. PMID: 38687615 Free article.
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population.
Indrihutami K, Chand K, Fahmia R, Rahardjani M, Wulandari F, Subekti D, Noviyanti R, Soebandrio A, Mallisa NT, Mardika IM, Budiman W, Suriswan I, Ertanto Y, Chen MC, Murshedkar T, Abebe Y, Sim BKL, Hoffman SL, Richie TL, Chen S, Elyazar IRF, Ekawati LL, Baird JK, Nelwan EJ. Indrihutami K, et al. Among authors: sim bkl. Am J Trop Med Hyg. 2024 Mar 26;110(5):892-901. doi: 10.4269/ajtmh.23-0597. Print 2024 May 1. Am J Trop Med Hyg. 2024. PMID: 38531102 Free PMC article. Clinical Trial.
Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria.
Watson FN, Shears MJ, Kalata AC, Duncombe CJ, Seilie AM, Chavtur C, Conrad E, Cruz Talavera I, Raappana A, Sather DN, Chakravarty S, Sim BKL, Hoffman SL, Tsuji M, Murphy SC. Watson FN, et al. Among authors: sim bkl. Sci Rep. 2024 Feb 4;14(1):2881. doi: 10.1038/s41598-024-53118-9. Sci Rep. 2024. PMID: 38311678 Free PMC article.
Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults.
Jongo S, Church LWP, Milando F, Qassim M, Schindler T, Rashid M, Tumbo A, Nyaulingo G, Bakari BM, Athuman Mbaga T, Mohamed L, Kassimu K, Simon BS, Mpina M, Zaidi I, Duffy PE, Swanson PA 2nd, Seder R, Herman JD, Mendu M, Zur Y, Alter G, Kc N, Riyahi P, Abebe Y, Murshedkar T, James ER, Billingsley PF, Sim BKL, Richie TL, Daubenberger C, Abdulla S, Hoffman SL. Jongo S, et al. Among authors: sim bkl. J Clin Invest. 2024 Jan 9;134(6):e169060. doi: 10.1172/JCI169060. J Clin Invest. 2024. PMID: 38194272 Free PMC article. Clinical Trial.
439 results