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White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. Fernando MS, et al. Among authors: simpson je. Stroke. 2006 Jun;37(6):1391-8. doi: 10.1161/01.STR.0000221308.94473.14. Epub 2006 Apr 20. Stroke. 2006. PMID: 16627790
White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neuropathol Appl Neurobiol. 2007 Aug;33(4):410-9. doi: 10.1111/j.1365-2990.2007.00828.x. Epub 2007 Apr 18. Neuropathol Appl Neurobiol. 2007. PMID: 17442062
Microglial activation in white matter lesions and nonlesional white matter of ageing brains.
Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neuropathol Appl Neurobiol. 2007 Dec;33(6):670-83. doi: 10.1111/j.1365-2990.2007.00890.x. Neuropathol Appl Neurobiol. 2007. PMID: 17990995
Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain.
Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neurobiol Aging. 2010 Apr;31(4):578-90. doi: 10.1016/j.neurobiolaging.2008.05.015. Epub 2008 Jun 30. Neurobiol Aging. 2010. PMID: 18586353
Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.
Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; Medical Research Council Cognitive Function and Ageing Study Neuropathology Group. Simpson JE, et al. Stroke. 2009 Feb;40(2):369-75. doi: 10.1161/STROKEAHA.108.529214. Epub 2008 Dec 24. Stroke. 2009. PMID: 19109541
Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia.
Wharton SB, O'Callaghan JP, Savva GM, Nicoll JA, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. Wharton SB, et al. Among authors: simpson je. Dement Geriatr Cogn Disord. 2009;27(5):465-73. doi: 10.1159/000217729. Epub 2009 May 7. Dement Geriatr Cogn Disord. 2009. PMID: 19420941
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neuropathol Appl Neurobiol. 2010 Feb;36(1):25-40. doi: 10.1111/j.1365-2990.2009.01030.x. Epub 2009 May 5. Neuropathol Appl Neurobiol. 2010. PMID: 19422529
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.
Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neurobiol Aging. 2011 Oct;32(10):1795-807. doi: 10.1016/j.neurobiolaging.2011.04.013. Epub 2011 Jun 25. Neurobiol Aging. 2011. PMID: 21705112
5,291 results