Simpson ML - Search Results

1

Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels.

Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS. Dar RD, et al. Among authors: simpson ml. PLoS One. 2016 Jul 28;11(7):e0158298. doi: 10.1371/journal.pone.0158298. eCollection 2016. PLoS One. 2016. PMID: 27467384 Free PMC article.

2

The Low Noise Limit in Gene Expression.

Dar RD, Razooky BS, Weinberger LS, Cox CD, Simpson ML. Dar RD, et al. Among authors: simpson ml. PLoS One. 2015 Oct 21;10(10):e0140969. doi: 10.1371/journal.pone.0140969. eCollection 2015. PLoS One. 2015. PMID: 26488303 Free PMC article.

3

Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean.

Razooky BS, Cao Y, Hansen MMK, Perelson AS, Simpson ML, Weinberger LS. Razooky BS, et al. Among authors: simpson ml. PLoS Biol. 2017 Oct 18;15(10):e2000841. doi: 10.1371/journal.pbio.2000841. eCollection 2017 Oct. PLoS Biol. 2017. PMID: 29045398 Free PMC article.

4

A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization.

Hansen MMK, Wen WY, Ingerman E, Razooky BS, Thompson CE, Dar RD, Chin CW, Simpson ML, Weinberger LS. Hansen MMK, et al. Among authors: simpson ml. Cell. 2018 Jun 14;173(7):1609-1621.e15. doi: 10.1016/j.cell.2018.04.005. Epub 2018 May 10. Cell. 2018. PMID: 29754821 Free PMC article.

5

Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability.

Hansen MMK, Desai RV, Simpson ML, Weinberger LS. Hansen MMK, et al. Among authors: simpson ml. Cell Syst. 2018 Oct 24;7(4):384-397.e6. doi: 10.1016/j.cels.2018.08.002. Epub 2018 Sep 19. Cell Syst. 2018. PMID: 30243562 Free PMC article.

6

Transient-mediated fate determination in a transcriptional circuit of HIV.

Weinberger LS, Dar RD, Simpson ML. Weinberger LS, et al. Among authors: simpson ml. Nat Genet. 2008 Apr;40(4):466-70. doi: 10.1038/ng.116. Epub 2008 Mar 16. Nat Genet. 2008. PMID: 18344999

7

Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression.

Singh A, Razooky B, Cox CD, Simpson ML, Weinberger LS. Singh A, et al. Among authors: simpson ml. Biophys J. 2010 Apr 21;98(8):L32-4. doi: 10.1016/j.bpj.2010.03.001. Biophys J. 2010. PMID: 20409455 Free PMC article.

8

Transcriptional burst frequency and burst size are equally modulated across the human genome.

Dar RD, Razooky BS, Singh A, Trimeloni TV, McCollum JM, Cox CD, Simpson ML, Weinberger LS. Dar RD, et al. Among authors: simpson ml. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17454-9. doi: 10.1073/pnas.1213530109. Epub 2012 Oct 11. Proc Natl Acad Sci U S A. 2012. PMID: 23064634 Free PMC article.

9

Resource Sharing Controls Gene Expression Bursting.

Caveney PM, Norred SE, Chin CW, Boreyko JB, Razooky BS, Retterer ST, Collier CP, Simpson ML. Caveney PM, et al. Among authors: simpson ml. ACS Synth Biol. 2017 Feb 17;6(2):334-343. doi: 10.1021/acssynbio.6b00189. Epub 2016 Sep 26. ACS Synth Biol. 2017. PMID: 27690390

10

Frequency domain analysis of noise in simple gene circuits.

Cox CD, McCollum JM, Austin DW, Allen MS, Dar RD, Simpson ML. Cox CD, et al. Among authors: simpson ml. Chaos. 2006 Jun;16(2):026102. doi: 10.1063/1.2204354. Chaos. 2006. PMID: 16822034

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