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Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Martin H, et al. Among authors: sims e. J Clin Invest. 2013 Oct;123(10):4449-63. doi: 10.1172/JCI67509. Epub 2013 Sep 16. J Clin Invest. 2013. PMID: 24091327 Free PMC article.
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS, Kapur R. Mali RS, et al. Among authors: sims e. Cancer Cell. 2011 Sep 13;20(3):357-69. doi: 10.1016/j.ccr.2011.07.016. Cancer Cell. 2011. PMID: 21907926 Free PMC article.
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Mali RS, et al. Among authors: sims e. Blood. 2012 Sep 27;120(13):2669-78. doi: 10.1182/blood-2011-08-375873. Epub 2012 Jul 17. Blood. 2012. PMID: 22806893 Free PMC article.
Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.
Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Ramdas B, Mali RS, Li S, Hashino E, Takemoto C, Kapur R. Ma P, et al. Among authors: sims e. Mol Cell Biol. 2011 Oct;31(19):4052-62. doi: 10.1128/MCB.05750-11. Epub 2011 Jul 26. Mol Cell Biol. 2011. PMID: 21791602 Free PMC article.
397 results