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A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes.
Salloum D, Singh K, Davidson NR, Cao L, Kuo D, Sanghvi VR, Jiang M, Lafoz MT, Viale A, Ratsch G, Wendel HG. Salloum D, et al. Among authors: singh k. J Immunol. 2022 Sep 15;209(6):1189-1199. doi: 10.4049/jimmunol.2100537. Epub 2022 Aug 24. J Immunol. 2022. PMID: 36002234 Free PMC article.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA Jr, Pelletier J, Rätsch G, Wendel HG. Wolfe AL, et al. Among authors: singh k. Nature. 2014 Sep 4;513(7516):65-70. doi: 10.1038/nature13485. Epub 2014 Jul 27. Nature. 2014. PMID: 25079319 Free PMC article.
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC.
Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein RA, Knauf JA, Rätsch G, Fagin JA. Krishnamoorthy GP, et al. Among authors: singh k. Cancer Discov. 2019 Feb;9(2):264-281. doi: 10.1158/2159-8290.CD-18-0606. Epub 2018 Oct 10. Cancer Discov. 2019. PMID: 30305285 Free PMC article.
c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma.
Singh K, Lin J, Zhong Y, Burčul A, Mohan P, Jiang M, Sun L, Yong-Gonzalez V, Viale A, Cross JR, Hendrickson RC, Rätsch G, Ouyang Z, Wendel HG. Singh K, et al. J Exp Med. 2019 Jul 1;216(7):1509-1524. doi: 10.1084/jem.20181726. Epub 2019 May 29. J Exp Med. 2019. PMID: 31142587 Free PMC article.
O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X. Singh JP, et al. Among authors: singh k. Oncogene. 2020 Jan;39(3):560-573. doi: 10.1038/s41388-019-0975-3. Epub 2019 Sep 9. Oncogene. 2020. PMID: 31501520 Free PMC article.
Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol.
Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Wendel HG, Hartmann RK, Ziebuhr J, Grünweller A. Müller C, et al. Among authors: singh k. Antiviral Res. 2020 Mar;175:104706. doi: 10.1016/j.antiviral.2020.104706. Epub 2020 Jan 10. Antiviral Res. 2020. PMID: 31931103 Free PMC article.
NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy.
Sanghvi VR, Mohan P, Singh K, Cao L, Berishaj M, Wolfe AL, Schatz JH, Lailler N, de Stanchina E, Viale A, Wendel HG. Sanghvi VR, et al. Among authors: singh k. Cancers (Basel). 2021 Feb 5;13(4):639. doi: 10.3390/cancers13040639. Cancers (Basel). 2021. PMID: 33562682 Free PMC article.
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Singh K, Lin J, Lecomte N, Mohan P, Gokce A, Sanghvi VR, Jiang M, Grbovic-Huezo O, Burčul A, Stark SG, Romesser PB, Chang Q, Melchor JP, Beyer RK, Duggan M, Fukase Y, Yang G, Ouerfelli O, Viale A, de Stanchina E, Stamford AW, Meinke PT, Rätsch G, Leach SD, Ouyang Z, Wendel HG. Singh K, et al. Cancer Res. 2021 Apr 15;81(8):2002-2014. doi: 10.1158/0008-5472.CAN-20-2929. Epub 2021 Feb 25. Cancer Res. 2021. PMID: 33632898 Free PMC article.
9,413 results