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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Among authors: singh sb. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421
Discovery of FabH/FabF inhibitors from natural products.
Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J. Young K, et al. Among authors: singh sb. Antimicrob Agents Chemother. 2006 Feb;50(2):519-26. doi: 10.1128/AAC.50.2.519-526.2006. Antimicrob Agents Chemother. 2006. PMID: 16436705 Free PMC article.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB. Wang J, et al. Among authors: singh sb. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. doi: 10.1073/pnas.0700746104. Epub 2007 Apr 24. Proc Natl Acad Sci U S A. 2007. PMID: 17456595 Free PMC article.
Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.
Jayasuriya H, Herath KB, Zhang C, Zink DL, Basilio A, Genilloud O, Diez MT, Vicente F, Gonzalez I, Salazar O, Pelaez F, Cummings R, Ha S, Wang J, Singh SB. Jayasuriya H, et al. Among authors: singh sb. Angew Chem Int Ed Engl. 2007;46(25):4684-8. doi: 10.1002/anie.200701058. Angew Chem Int Ed Engl. 2007. PMID: 17487925 No abstract available.
Biosynthetic studies of platensimycin.
Herath KB, Attygalle AB, Singh SB. Herath KB, et al. Among authors: singh sb. J Am Chem Soc. 2007 Dec 19;129(50):15422-3. doi: 10.1021/ja0758943. Epub 2007 Nov 23. J Am Chem Soc. 2007. PMID: 18034483 No abstract available.
Synthesis and biological evaluation of platensimycin analogs.
Shen HC, Ding FX, Singh SB, Parthasarathy G, Soisson SM, Ha SN, Chen X, Kodali S, Wang J, Dorso K, Tata JR, Hammond ML, Maccoss M, Colletti SL. Shen HC, et al. Among authors: singh sb. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1623-7. doi: 10.1016/j.bmcl.2009.02.006. Epub 2009 Feb 7. Bioorg Med Chem Lett. 2009. PMID: 19233644
799 results